... mesoderm (PSM) despite considerable variation in PSM length across developmental stages and in surgically size-reduced embryos. Measurement of clock period, axis elongation speed and clock gene expression patterns demonstrate that existing models fail to explain scaling. We posit a ‘clock and scaled...

.... To improve our volume measurements, we used tissue-specific marker expression to delimit areas with low morphological cues; for example, the boundary between the lateral plate and PSM or between the tip of the notochord and progenitor zone. We performed immunostaining with the pan-neural marker Sox2 and pan...

...Ravindra B. Chalamalasetty; Robert J. Garriock; William C. Dunty, Jr; Mark W. Kennedy; Parthav Jailwala; Han Si; Terry P. Yamaguchi Neuromesodermal (NM) stem cells generate neural and paraxial presomitic mesoderm (PSM) cells, which are the respective progenitors of the spinal cord...