...Junji Zhu; Dawei Zhang; Xing Liu; Guangqing Yu; Xiaolian Cai; Chenxi Xu; Fangjing Rong; Gang Ouyang; Jing Wang; Wuhan Xiao ABSTRACT Protein arginine methyltransferase 5 (Prmt5), a type II arginine methyltransferase, symmetrically dimethylates arginine in nuclear and cytoplasmic proteins. Prmt5...

... preserving their capacity to differentiate is unknown. Here, we report that the arginine methyltransferase PRMT5 has a crucial role in maintaining progenitor cells. Mouse embryonic buds lacking PRMT5 have severely truncated bones with wispy digits lacking joints. This novel phenotype is caused by widespread...

... of symmetrical dimethylarginine (sDMA) on chromatoid body components and identify the ortholog of protein arginine methyltransferase PRMT5 as the enzyme responsible for sDMA modification in these proteins. RNA interference-mediated depletion of planarian PRMT5 results in defects in homeostasis and regeneration...

...., Kouzarides, T. and Surani, M. A. ( 2006 ). Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat. Cell Biol . 8 , 623 -630. Anne, J. and Mechler, B. M. ( 2005 ). Valois, a component of the nuage and pole plasm, is involved in assembly of these structures...