... for the cataract-linked transcription factor MAF, is established across a temporal trajectory of fiber cell differentiation. Furthermore, we identify an epigenetic paradigm of cellular differentiation, defined by progressive loss of the H3K27 methylation writer Polycomb repressive complex 2 (PRC2). PRC2 localizes...

...Sara A. Miller; Manashree Damle; Jongmin Kim; Robert E. Kingston ABSTRACT Polycomb repressive complex 2 (PRC2) catalyzes methylation of histone H3 on lysine 27 and is required for normal development of complex eukaryotes. The nature of that requirement is not clear. H3K27me3 is associated...

...Orla Deevy; Adrian P. Bracken ABSTRACT Polycomb repressive complex 2 (PRC2) is a conserved chromatin regulator that is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for normal development and its loss of function thus results in a range of developmental...

...Chunming Guo; Zarine R. Balsara; Warren G. Hill; Xue Li ABSTRACT Urothelium is the protective lining of the urinary tract. The mechanisms underlying urothelial formation and maintenance are largely unknown. Here, we report the stage-specific roles of PRC2 epigenetic regulators in embryonic...

...Anne Grijzenhout; Jonathan Godwin; Haruhiko Koseki; Michal Ryszard Gdula; Dorota Szumska; Joanna F. McGouran; Shoumo Bhattacharya; Benedikt M. Kessler; Neil Brockdorff; Sarah Cooper The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular...

..., we report that cerebellar deletion of Ezh2, the methyltransferase subunit of the PRC2 complex, results in reduced H3K27me3 and profound transcriptional dysregulation, including that of a set of transcription factors directly involved in cerebellar neuronal cell-type specification and differentiation...

... 2 (PRC2) near the Fgf8 RARE. The co-regulator RERE, the loss of which results in ectopic Fgf8 expression and somite defects, was recruited near the RARb RARE by RA, but was released from the Fgf8 RARE by RA. Our findings demonstrate that RA directly represses Fgf8 through a RARE-mediated mechanism...

... ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 22 4 2011 © 2011. 2011 Arabidopsis Retinoblastoma RBR ABI3, Polycomb PRC2 Cell fate Cell cycle Differentiation Seedling establishment Embryo development Tumor...