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Keywords: PRAMEL1
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Journal Articles

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis

Mingyao Yang, Wenzhi Ma, Jon Oatley, Wan-Sheng Liu
Journal: Development
Development (2023) 150 (21): dev201907.
https://doi.org/10.1242/dev.201907
Published: 27 October 2023
... in this process are not fully understood. Here, we report findings on the involvement of a cancer/testis antigen, PRAMEL1, in the initiation and maintenance of spermatogenesis. By analyzing mouse models with either global or conditional Pramel1 inactivation , we found that PRAMEL1 regulates the RA responsiveness...
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Includes: Supplementary data