...Ling Pan; Zhiyong Yang; Liang Feng; Lin Gan POU-domain transcription factors play essential roles in cell proliferation and differentiation. Previous studies have shown that targeted deletion of each of the three POU-domain Brn3 factors in mice leads to the developmental failure and apoptosis...

...S. Raisa Eng; Jason Lanier; Natalia Fedtsova; Eric E. Turner Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis. We have determined the regulatory targets of Brn3a in the developing trigeminal ganglion using microarray...

... are located in the lateral PNS cluster. Mutations in the u-turn ( ut ) locus perturb the localization of lch5 neurons and result in a `dorsal chordotonals' phenotype. We show that ut is allelic to ventral veinless ( vvl ), also known as drifter . VVL, a POU-domain transcription factor, has been shown...

...May Trieu; Ann Ma; S. Raisa Eng; Natalia Fedtsova; Eric E. Turner Brn3a is a POU-domain transcription factor expressed in peripheral sensory neurons and in specific interneurons of the caudal CNS. Sensory expression of Brn3a is regulated by a specific upstream enhancer, the activity of which...