... that ubiquitylation may be involved in GlyT1a degradation. The clathrin inhibitor blocked GlyT1a internalization. Strikingly, the protein kinase C (PKC) activator triggered the heterochronic internalization of GlyT1a; the PKC inhibitor markedly blocked GlyT1a endocytosis. Lastly, clathrin inhibition completely...

...Tetsuhisa Otani; Yosuke Ogura; Kazuyo Misaki; Takuya Maeda; Akiyo Kimpara; Shigenobu Yonemura; Shigeo Hayashi Signaling molecules have pleiotropic functions and are activated by various extracellular stimuli. Protein kinase C (PKC) is activated by diverse receptors, and its dysregulation...

... show that two parallel pathways are involved in the neuralising activity of Syn4: FGF/ERK, which is sensitive to dominant-negative FGF receptor and to the inhibitors SU5402 and U0126, and a PKC pathway, which is dependent on the intracellular domain of Syn4. Neural induction by Syn4 through the PKC...

...., Yoshinaga, S., Takeya, R., Suzuki, N. N., Horiuchi,M., Kohjima, M., Sumimoto, H. and Inagaki, F. ( 2005 ). Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains. J. Biol. Chem. 280 , 9653 -9661. Hutterer, A., Betschinger, J., Petronczki, M. and Knoblich, J...

... for correspondence (e-mail: [email protected] ) 02 09 200 10 09 2000 © 2000 by Company of Biologists 2000 Xenopus laevis PKC ASIP PAR Asymmetry Polarity Oocyte Meiotic maturation The asymmetric localization of cytoplasmic components is the basis for the cell fate...

... in mice lacking MARCKS, the major substrate of protein kinase C (PKC), and we have found that p190 RhoGAP is also a PKC substrate in vivo. Upon either direct activation of PKC or in response to integrin engagement, p190 RhoGAP is rapidly translocated to regions of membrane ruffling, where it colocalizes...

... genes. The sensitivity of the upregulation of neurectodermal markers to GF109203X indicates that the activity of a calcium activated protein kinase C (PKC) is also required. Furthermore ectopic expression of mouse eIF4AII mRNA upregulates the endogenous eIF4AII gene by a process that requires...

... by Company of Biologists 1995 kidney development morphogenesis branching glycosaminoglycans PKC hepatocyte growth factor mouse Little is known about the mechanisms that regulate epithelial differentiation and morphogenesis during embryonic development (for reviews see Fleming, 1992...