.... References Abd Halim , K. B. , Koldsø , H. and Sansom , M. S. P. ( 2015 ). Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations . Biochim. Biophys. Acta 1850 , 1017 - 1025 . 10.1016/j.bbagen...

...: 10 µm. Fig. 4. Coupling between PIP2 cortical structures and F-actin. (A) Spinning disk confocal cortical imaging of embryos expressing mNG::PHPLC1δ1 and Lifeact::mKate-2 (first column), corresponding binary thresholded images (second column) and PIV velocity vectors (third column), with high...

... cytoskeleton required for the asymmetric transport of oskar, bicoid and gurken mRNAs and thereby controls the establishment of cell polarity. We show that Skittles function is crucial to synthesize and maintain phosphatidylinositol 4,5 bisphosphate (PIP2) at the plasma membrane in the oocyte. Reduction...

.... fwd is shown to encode a phosphatidylinositol 4-kinase (PI 4-kinase), a member of a family of proteins that perform the first step in the synthesis of the key regulatory membrane phospholipid PIP2. Wild-type activity of the fwd PI 4-kinase is required for tyrosine phosphorylation in the cleavage...