... PIE-1 MES-2 MES-6 transcriptional repression P granules germline Caenorhabditis elegans The mechanisms that set the germline apart from the soma have fascinated biologists since the work of Weismann in the late 1800s ( Weismann, 1893 ). Several developmental characteristics distinguish...

... by abnormal-looking centrosomes. In addition to its requirement during mitosis, AIR-1 may regulate microtubule-based developmental processes as well. Our data suggests AIR-1 plays a role in P-granule segregation and the association of the germline factor PIE-1 with centrosomes. * Current address...

.... (e-mail: [email protected] ) 28 07 1997 © 1997 by Company of Biologists 1997 Caenorhabditis elegans pattern formation vab-7 lp-1 apx-1 skn-1 pie-1 mex-3 pal-1 heat shock The study of numerous maternal effect genes in the C. elegans embryo has...

... of the mex-1 gene products. The MEX-1 protein contains two copies of an unusual ‘finger’ domain also found in the PIE-1 protein of C . elegans . PIE-1 has been shown to be expressed in germline blastomeres, and is a component of P granules. We show here that MEX-1 also is present in germline blastomeres...

... three cell cycles. Second, induction on one side of the EMS cell usually blocks the other side from responding to a second P 2 -derived signal. Third, microfilaments and microtubules may be required near the time of the interaction for subsequent gut differentiation. Lastly, cell manipulations in pie-1...

... equivalence of ABa and ABp. We performed two independent tests of this model. First, we examined ABp development in pie-1 mutant embryos, in which P 2 adopts the identity of another blastomere. We find that, in pie-1 embryos, ABp fails to produce its char- acteristic cell types and instead adopts a fate...