... ). This reorganization requires activation of the insulin receptor-insulin receptor substrate-PI3K pathway ( Tsakiridis et al., 1999 ), which results in the production of phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5) P 3 , PIP3] and recruitment of PIP3-binding proteins to the plasma membrane to initiate...

..., and single-cell analysis of morphology and cell dynamics, we determined that endocrine cell motility is regulated by phosphoinositide 3-kinase (PI3K) and G-protein-coupled receptor (GPCR) signaling. Linking cell dynamics to islet formation, perturbation of protrusion formation disrupted endocrine cell...

... cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic...

...Jason S. L. Yu; Wei Cui Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions...

..., PI3K. Among the known Dpp targets, vestigial was the only one tested that was required for Tkv Q253D -induced growth. The growth response to altering Dpp signaling varied regionally and temporally in the wing disc, indicating that other patterned factors modify the response. y w hs-flp 122 ; cdk4 3...

...Rosa Carballada; Hitoyoshi Yasuo; Patrick Lemaire ABSTRACT Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that can phosphorylate phosphaditylinositides leading to the cell type-specific regulation of intracellular protein kinases. PI3Ks are involved in a wide variety of cellular events...