...Anne Bourdais; Patricia Viard; Jenny Bormann; Côme Sesboüé; Daniel Guerrier; Nicole Therville; Julie Guillermet-Guibert; John Carroll; Guillaume Halet The PI3K/Akt pathway is thought to regulate key steps of mammalian oogenesis, such as dormant oocyte awakening during follicular activation, meiotic...

... by Smad6 deletion in endothelial cells in vivo . At the cellular level, co-depletion of Smad6 and Alk1 rescued the destabilized junctions and impaired barrier function of endothelial cells depleted for SMAD6 alone. Mechanistically, blockade of actomyosin contractility or increased PI3K signaling rescued...

... to maintain escort cell cellular protrusion and survival for Drosophila ovarian germline stem cell maintenance and soma-germline interactions. Insulin/IGF PI3K S6K Fax Failed axon connections Escort cell GSC Niche Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan...

..., and single-cell analysis of morphology and cell dynamics, we determined that endocrine cell motility is regulated by phosphoinositide 3-kinase (PI3K) and G-protein-coupled receptor (GPCR) signaling. Linking cell dynamics to islet formation, perturbation of protrusion formation disrupted endocrine cell...

... cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic...

...Jason S. L. Yu; Wei Cui Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions...

..., PI3K. Among the known Dpp targets, vestigial was the only one tested that was required for Tkv Q253D -induced growth. The growth response to altering Dpp signaling varied regionally and temporally in the wing disc, indicating that other patterned factors modify the response. *Author...

...Rosa Carballada; Hitoyoshi Yasuo; Patrick Lemaire ABSTRACT Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that can phosphorylate phosphaditylinositides leading to the cell type-specific regulation of intracellular protein kinases. PI3Ks are involved in a wide variety of cellular events...