... to the early inner cell mass, and subsequently identifying presumptive hypoblast, is PDGFRA, followed by SOX17, FOXA2 and GATA4 in sequence as the hypoblast becomes committed. References Artus , J. , Piliszek , A. and Hadjantonakis , A. K. (2011). The primitive endoderm lineage...

... development. Alveolar pathologies are prominent in neonatal and adult lung diseases. The mechanisms of alveologenesis remain largely unknown. We inactivated Pdgfra postnatally in secondary crest myofibroblasts (SCMF), a subpopulation of lung mesenchymal cells. Lack of Pdgfra arrested alveologenesis akin...

... sensitivity to ethanol teratogenesis are largely unknown. To identify potential ethanol-sensitive genes, we tested five known craniofacial mutants for ethanol sensitivity: cyp26b1, gata3, pdgfra, smad5 and smoothened . We found that only platelet-derived growth factor receptor alpha (pdgfra) interacted...

... endoderm Epiblast Pdgfra Pluripotency Cell plasticity Pre-implantation mammalian development is primarily dedicated to the allocation of two extra-embryonic lineages: trophoblast and PrE. Signalling pathways operating in the early mammalian embryo direct differentiation and segregation...

...Avi Orr-Urtreger; Peter Lonai ABSTRACT The localized developmental expression of murine platelet-derived growth factor A (PDGF-A) was compared to that of itsreceptor (Pdgfra). Our in situ hybridization study included germ layers of primitive streak embryos, early axial structures (dermatome...