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Keywords: PCP
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev200136.
Published: 3 May 2022
... to be dependent on cilia-driven fluid flow in the embryonic node. Planar cell polarity (PCP) signalling is crucial for patterning of nodal cilia, yet downstream effectors driving this process remain elusive. We have examined the role of the JNK gene family, a proposed downstream component of PCP signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev198952.
Published: 7 September 2021
....02427 Merkel , M. , Sagner , A. , Gruber , F. S. , Etournay , R. , Blasse , C. , Myers , E. , Eaton , S. and Jülicher , F. ( 2014 ). The balance of prickle/spiny-legs isoforms controls the amount of coupling between core and fat PCP systems . Curr. Biol. 24...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186346.
Published: 21 December 2020
...Marek Mlodzik ABSTRACT Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium. PCP is crucial during many biological patterning processes and for organ function. It is omnipresent, from convergent-extension mechanisms during early development through to terminal...
Journal Articles
Journal: Development
Development (2018) 145 (8): dev163824.
Published: 13 April 2018
...Bo Gao; Rieko Ajima; Wei Yang; Chunyu Li; Hai Song; Matthew J. Anderson; Robert R. Liu; Mark B. Lewandoski; Terry P. Yamaguchi; Yingzi Yang ABSTRACT Embryonic morphogenesis of a complex organism requires proper regulation of patterning and directional growth. Planar cell polarity (PCP) signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3869–3881.
Published: 15 September 2013
...Praveer Sharma; Helen McNeill Fat (Ft) and Dachsous (Ds) are large cadherins that bind each other and have conserved roles in regulating planar cell polarity (PCP). We quantitatively analyzed Ft-Ds pathway mutant clones for their effects on ommatidial polarity in the Drosophila eye. Our findings...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (10): 2061–2074.
Published: 15 May 2013
... is understanding how such patterns of lateral and longitudinal coordination may be established over extended domains. PCP PIN Auxin Organiser Polarity © 2013. Published by The Company of Biologists Ltd 2013 Competing interests statement The authors declare no competing financial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1693–1702.
Published: 15 April 2013
.... Planar polarity PCP Ubiquitination Neddylation Dishevelled Drosophila Polarisation of cells in the plane of an epithelium is essential for morphogenesis and depends on a group of core planar polarity proteins (the ‘core proteins’), the function of which is conserved among...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1785–1795.
Published: 15 April 2013
...Conor W. Sipe; Lixia Liu; Jianyi Lee; Cynthia Grimsley-Myers; Xiaowei Lu The V-shaped hair bundles atop auditory hair cells and their uniform orientation are manifestations of epithelial planar cell polarity (PCP) required for proper perception of sound. PCP is regulated at the tissue level...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 831–842.
Published: 15 February 2013
...Guohui Pan; Yongqiang Feng; Abhijit A. Ambegaonkar; Gongping Sun; Matthew Huff; Cordelia Rauskolb; Kenneth D. Irvine The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways. Here we investigate the molecular basis for signal transduction downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1498–1508.
Published: 15 April 2012
...Hitoshi Matakatsu; Seth S. Blair The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP). Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki). Much of Ft activity is likely to be mediated...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (19): 3223–3233.
Published: 1 October 2009
... segments, including the femur and tibia were both shorter and broader ( Fig. 3K-N ). In addition, fat 1 lft TG2 double mutants had only four tarsal segments instead of the usual five( Fig. 3N ), a phenotype that is characteristic of mutations in fat pathway genes. Finally, we did not observe PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 3019–3030.
Published: 1 September 2009
... required for cilia-driven fluid flow. Furthermore,depending on its SAM domain, BicC can uncouple Dvl2 signaling from the canonical Wnt pathway, which has been implicated in antagonizing planar cell polarity (PCP). The SAM domain concentrates BicC in cytoplasmic structures harboring RNA-processing bodies (P...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1771–1780.
Published: 15 May 2008
..., but not for NC induction. Inhibition of Syn4 does not affect the velocity of cell migration, but significantly reduces the directional migration of NC cells. Furthermore, we show that Syn4 and PCP signaling control the directional migration of NC cells by regulating the direction in which the cell protrusions...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 151–161.
Published: 1 January 2006
... planar cell polarity (PCP) pathways downstream of Wnt4 positively regulate the colony size, and that the JNK pathway is also involved in mesenchymal-to-epithelial transformation of colony-forming progenitors. Thus our colony-forming assay, which identifies multipotent progenitors in the embryonic mouse...
Journal Articles
Journal: Development
Development (2005) 132 (11): 2587–2597.
Published: 1 June 2005
... that the non-canonical Wnt signalling [planar cell polarity (PCP) or Wnt-Ca 2+ ] pathway controls migration of neural crest cells. By using specific Dsh mutants, we show that the canonical Wnt signalling pathway is needed for neural crest induction, while the non-canonical Wnt pathway is required for neural...
Journal Articles
Journal: Development
Development (2004) 131 (18): 4467–4476.
Published: 15 September 2004
...Gishnu Das; Andreas Jenny; Thomas J. Klein; Suzanne Eaton; Marek Mlodzik Planar cell polarity (PCP) in the Drosophila eye is established by the distinct fate specifications of photoreceptors R3 and R4, and is regulated by the Frizzled (Fz)/PCP signaling pathway. Before the PCP proteins become...