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Keywords: PAX3
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Journal Articles
Journal: Development
Development (2016) 143 (5): 872–879.
Published: 01 March 2016
...Alicia Mayeuf-Louchart; Didier Montarras; Catherine Bodin; Tsutomu Kume; Stéphane D. Vincent; Margaret Buckingham Pax3 and Foxc2 have been shown genetically to mutually repress each other in the mouse somite. Perturbation of this balance in multipotent cells of the dermomyotome influences cell fate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 2972–2984.
Published: 15 July 2013
...), which is crucial for voluntary swallowing, arise from Pax3 -expressing somite cells. In vivo Kaede lineage tracing in zebrafish reveals the migratory route of cells from the anteriormost somites to OSM and SHM destinations. Expression of pax3b , a zebrafish duplicate of Pax3 , is restricted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4220–4231.
Published: 15 November 2012
... signals. Changes in the relative influence of these enhancers could thus cause zic3 and pax3/7 expression to respond differently to Wnt and FGF perturbations in different species. For example, if pax3a IR1 was lost, or pax3a IR2 somehow became dominant, pax3a would appear to be Wnt independent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 277–287.
Published: 15 January 2012
... role of this latter cell type in myoblast guidance. By creating a new Flk1/Pax3 double reporter mouse line, we have established the precise timetable for angioblast and myoblast delamination/migration from the somite to the limb bud. This timetable was conserved when mouse PSM was grafted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (19): 3267–3278.
Published: 01 October 2009
... and the inhibition of preplacodal genes such as Six1 . In addition, we demonstrate that Gbx2 is upstream of the neural fold specifiers Pax3 and Msx1 . Our results place Gbx2 as the earliest factor in the NC genetic cascade being directly regulated by the inductive molecules, and support the notion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1849–1858.
Published: 01 June 2009
... phenotype. Ectopic expression of FOXD3 represses MITF in cultured neural crest cells and in B16-F10 melanoma cells. We also show that FOXD3 does not bind directly to the MITF promoter, but instead interacts with the transcriptional activator PAX3 to prevent the binding of PAX3 to the MITF promoter...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 403–414.
Published: 01 February 2009
... ( myf6 ) myod myf5 Myogenin Hedgehog prdm1 pax3 meox1 hsp90 mef2d Motility is a key determinant of evolutionary success. During vertebrate evolution, somitic, appendicular and head muscle has undergone significant adaptation as fish evolved and moved onto land. One major...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3577–3586.
Published: 01 November 2008
... anomalous great arteries owing to a failure to establish the initial complement of branchial arch arteries in the caudal pharyngeal region. Pbx1 deficiency also results in the failure of cardiac OFT septation. Pbx1 -null embryos lose a transient burst of Pax3 expression in premigratory cardiac neural crest...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (12): 2325–2335.
Published: 15 June 2006
... for mammary line and placode formation. The mammary line is displaced dorsally, and formation of placode 3 is impaired in Pax3 ILZ/ILZ mutants, which do not form ventral somitic buds. Mammary line formation is impaired and placode 3 is absent in Gli3 Xt-J/Xt-J and hypomorphic Fgf10 mutants, in which...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1101–1112.
Published: 15 March 2006
..., composed of at least bipotent cells, colonizes both the subectodermal space to generate dermis, and the myotome to give rise to the majority of mitotic muscle progenitors, a population that maintains the expression of DM markers, such as PAX3, PAX7 and FREK( Ben-Yair and Kalcheim, 2005 ; Ben-Yair et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 737–749.
Published: 15 February 2006
... is predominantly in the hypaxial somite, adjacent to labelled smooth muscle cells in the aorta. Analysis of Pax3 GFP/+ embryos shows that these cells are Pax3 negative but GFP positive, with fluorescent cells in the intervening region between the aorta and the somite. This is consistent with the direct migration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2355–2363.
Published: 15 May 2005
... function of Pax3 and Zic1 determines the neural crest fate in the amphibian ectoderm. Pax3 and Zic1 are expressed in an overlapping manner in the presumptive neural crest area of the Xenopus gastrula, even prior to the onset of the expression of the early bona fide neural crest marker genes Foxd3 and Slug...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (9): 2235–2249.
Published: 01 May 2005
.... At the limb bud level, Six1 and Six4 homeogenes control early steps of myogenic cell delamination and migration from the somite through the control of Pax3 gene expression. Impaired in their migratory pathway, cells of the somitic ventrolateral dermomyotome are rerouted, lose their identity and die...
Journal Articles
Journal: Development
Development (2005) 132 (4): 689–701.
Published: 15 February 2005
... that maintain expression of PAX7,PAX3 and FREK. Given this dual fate, we asked whether single dermomyotome precursors generate both dermal and mitotic myoblast precursors, or alternatively, whether these cell types derive from distinct epithelial founders. Inovo clonal analysis revealed that single dermomyotome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (3): 447–458.
Published: 01 February 2005
... the somites into the leg bud ( Chevallier et al.,1977 ; Jacob et al.,1979 ). We have detected single spindle shaped cells that express Pax3 but not MyoD during this initial phase of movement( Amthor et al., 1998 ). However,the situation is different as the cloacal anlage extends from the ventral muscle...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3249–3262.
Published: 15 July 2004
... the myogenic determination genes XMyf5 , XMyoD and Pax3 in a pattern reminiscent of amniote dermomyotome. Thus, Xenopus somites have characteristics in common with both fish and amniotes that shed light on the evolution of somite differentiation. We propose a model for the evolutionary adaptation of myogenesis...
Journal Articles
Journal: Development
Development (2004) 131 (4): 829–837.
Published: 15 February 2004
...Rita C. Milewski; Neil C. Chi; Jun Li; Christopher Brown; Min Min Lu; Jonathan A. Epstein Pax3 is a transcription factor that is required by Pre-migratory neural crest cells give rise to the peripheral nervous system, melanocytes, some vascular smooth muscle, and numerous other derivatives...
Journal Articles
Journal: Development
Development (2003) 130 (21): 5103–5111.
Published: 01 November 2003
... of the scapular blade and of rostral ribs. Such dysmorphogenesis is preceded by ectopic Pax3 expression in the hypaxial part of the dermomyotome,a region from which the blade of the scapula normally derives. A mutant CPZ,lacking a critical active site glutamate, fails to induce Pax3 expression and does not cause...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2239–2252.
Published: 15 May 2003
...,distinct from those of other hypaxial determinants such as Pax3, cMet,Lbx1 or Mox2 . Markers of myogenic specification belong to the family of basic helix-loop-helix (bHLH) transcription factors composed of Myf5, MyoD, myogenin and Myf6 (MRF4). The different roles played in vivo by the myogenic...
Journal Articles
Journal: Development
Development (2002) 129 (2): 527–538.
Published: 15 January 2002
... of cranial neural crest migrate from the hindbrain into the outflow tract of the heart where they contribute to the septum that divides the pulmonary and aortic channels. In Splotch mutant mice, which lack a functional Pax3 gene, migration of cardiac neural crest is deficient and aorticopulmonary septation...