..., we demonstrate the existence of a second, parallel and redundant pathway that can polarize the zygote in the absence of ECT-2-dependent cortical flows. This second pathway depends on the polarity protein PAR-2. We show that PAR-2 localizes to the cortex nearest the sperm centrosome even...

... cell division. Independently of its role in meiotic progression, CUL-2 is required to limit the initiation/spread of the polarity protein PAR-2 in regions distant from microtubule organizing centers. Finally,we show that inactivation of the leucine-rich repeat protein ZYG-11 produces meiotic...

... -1075. Boyd, L., Guo, S., Levitan, D., Stinchcomb, D. T. and Kemphues, K. J. ( 1996 ). PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development 122 , 3075 -3084. Braet, F., de Zanger, R. and Wisse, E. ( 1997...

... par-1 par-2 par-3 par-4 skn-1 The generation of asymmetry before mitosis is a general mechanism for producing cells with different fates during growth and development (for a review, see Gonczy and Hyman, 1996 ). For example, sperm entry provides an extrinsic cue to polarize the 1...

...Lynn Boyd; Su Guo; Diane Levitan; Dan T. Stinchcomb; Kenneth J. Kemphues ABSTRACT The par genes participate in the process of establishing cellular asymmetries during the first cell cycle of Caenorhabditis elegans development. The par-2 gene is required for the unequal first cleavage...