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Keywords: PAR-1
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Journal Articles
Journal: Development
Development (2018) 145 (14): dev166165.
Published: 30 July 2018
..., par-1 and a regulatory subunit of Drosophila Myosin ( spaghetti squash ), we propose that Insulin signaling likely influences par-1 activity to engineer border cell detachment and subsequent movement via Drosophila Myosin. * Author for correspondence ( mohitprasad@iiserkol.ac.in ) Competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2984–2992.
Published: 01 August 2014
...Eurico Morais-de-Sá; Avik Mukherjee; Nick Lowe; Daniel St Johnston The Drosophila anterior-posterior axis is specified when the posterior follicle cells signal to polarise the oocyte, leading to the anterior/lateral localisation of the Par-6/aPKC complex and the posterior recruitment of Par-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5441–5450.
Published: 15 December 2011
... protein that is expressed in neuroectoderm adjacent to the NC territory, is required for NC formation. Wnt11-like signals might specify NC by altering the localization and activity of the serine/threonine polarity kinase PAR-1 (also known as microtubule-associated regulatory kinase or MARK), which itself...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (10): 1765–1773.
Published: 15 May 2010
... poles of the cell. Oocyte polarity has been proposed to depend on the same PAR proteins that generate AP polarity in C. elegans , with a complex of Bazooka (Baz; Par-3), Par-6 and aPKC marking the anterior and lateral cortex, and Par-1 defining the posterior. The function of the Baz complex in oocyte...
Journal Articles
Journal: Development
Development (2010) 137 (4): 661–670.
Published: 15 February 2010
... does not affect embryonic polarity. Instead, we found that the PAR-4-mediated phosphorylation of polarity regulators such as PAR-1 and MEX-5 in the early embryo occurs in the absence of STRD-1. Thus, PAR-4 requires STRD-1 to phosphorylate AMPK to regulate cell growth/proliferation under reduced insulin...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3665–3675.
Published: 15 November 2008
... polarity proteins. Through mechanisms that are not understood, the kinases PAR-1 and PAR-4, and other PAR proteins cause the cytoplasmic zinc finger protein MEX-5 to accumulate asymmetrically in the anterior half of the one-cell embryo. We show that MEX-5 asymmetry requires neither vectorial transport to...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 463–471.
Published: 01 February 2008
... oocyte posterior, thereby dividing the cortex into different domains along the AP axis. Active Lgl promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of the serine/threonine kinase Par-1, a key step for oocyte polarization. Our studies suggest that Lgl and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2747–2756.
Published: 15 July 2006
... orthologous to MELK, a conserved member of the polarity-regulating PAR-1/Kin1/SAD-1 family of serine/threonine kinases. Although MELK has been implicated in regulating the cell cycle, our data suggest that PIG-1, like other PAR-1 family members, regulates cell polarity. † Author for correspondence (e...
Journal Articles
Journal: Development
Development (2004) 131 (23): 5897–5907.
Published: 01 December 2004
...Veit Riechmann; Anne Ephrussi The Ser/Thr kinase Par-1 is required for cell polarisation in diverse organisms such as yeast, worms, flies and mammals. During Drosophila oogenesis, Par-1 is required for several polarisation events, including localisation of the anterior determinant bicoid . To...
Journal Articles
Journal: Development
Development (2004) 131 (4): 755–765.
Published: 15 February 2004
... sur-6 . Therefore,SUR-6 must influence Raf activity via a different mechanism. SUR-6 and KSR(kinase suppressor of Ras) function at a similar step in Raf activation but our genetic analysis suggests that KSR activity is intact in sur-6 mutants. We identify the kinase PAR-1 as a negative regulator of...
Journal Articles
Journal: Development
Development (2003) 130 (17): 3965–3975.
Published: 01 September 2003
...Hélène Doerflinger; Richard Benton; Joshua M. Shulman; Daniel St Johnston The PAR-1 kinase plays a conserved role in cell polarity in C. elegans,Drosophila and mammals. We have investigated the role of PAR-1 in epithelial polarity by generating null mutant clones in the Drosophila follicular...