...-mail: [email protected] ) 20 8 2003 © 2003. 2003 Drosophila Embryo Engulfment Apoptosis H99 p35 Phagocytosis The purpose of apoptosis is to orchestrate the orderly removal of cells from a tissue without spilling their contents into the intracellular space. In embryonic...

... of the caspase inhibitor p35 or removal of the pro-apoptotic genes reaper, hid and grim ,showing that the glial cell undergoes apoptosis. Moreover, it seems that fragments are eliminated from the epithelium by mobile macrophages. Forcing survival of the glial cells induces precocious axonal outgrowth but does...

... of these tissues can be inhibited by ectopic expression of the baculovirus antiapoptotic protein p35, implicating a role for caspases in the death response. Coordinate stage-specific induction of the Drosophila death genes reaper ( rpr ) and head involution defective ( hid ) immediately precedes the destruction...

...Bruce A. Hay; Tanya Wolff; Gerald M. Rubin ABSTRACT The baculovirus P35 protein functions to prevent apoptotic death of infected cells. We have expressed P35 in the developing embryo and eye of the fly Drosophila melanogaster . P35 eliminates most, if not all, normally occurring cell death...