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Keywords: P granules
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev195578.
Published: 27 November 2020
... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: PLP-1, the C. elegans ortholog of the conserved Pur-alpha proteins, functions downstream of small RNA biogenesis during initiation of gene silencing in the germ line. Pur-alpha puf-8 P granules piRNA Major...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev171116.
Published: 25 March 2019
... to the posterior cytoplasm of C. elegans zygotes. Polarity Kinase PAR proteins MEX-6 P granules PAR-3 Cell polarity is central to many cellular and developmental processes, such as axon specification, cell migration, tissue morphogenesis and asymmetric cell division. The kinase PAR-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1745–1755.
Published: 15 May 2015
...Anne C. Campbell; Dustin L. Updike Germ granules (P granules) in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency. Sterility in the absence of P granules is often accompanied by the misexpression of soma-specific proteins and the initiation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (8): 1305–1314.
Published: 15 April 2010
...Ujwal Sheth; Jason Pitt; Shannon Dennis; James R. Priess Germline-specific granules of unknown function are found in a wide variety of organisms, including C. elegans , where they are called P granules. P granules are cytoplasmic bodies in oocytes and early embryos. Throughout most of the C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2001) 128 (20): 3899–3912.
Published: 15 October 2001
.... elegans eIF4E, IFE-1, is enriched in the germline and is a component of germ granules (P granules). The association of IFE-1 with P granules requires the P-granule protein PGL-1. In vitro PGL-1 interacts directly with IFE-1, but not with the other four isoforms of eIF4E. Analysis of animals depleted...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (8): 1287–1298.
Published: 15 April 2001
...Jennifer A. Schisa; Jason N. Pitt; James R.Priess ABSTRACT P granules are cytoplasmic structures of unknown function that are associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle. All the known protein...
Journal Articles
Journal Articles
Journal: Development
Development (1999) 126 (21): 4861–4871.
Published: 1 November 1999
... from a maternal RNA associated with P granules, and is required for the efficient incorporation of PGCs into the somatic gonad. nos-1 is expressed in PGCs after gastrulation, and is required redundantly with nos-2 to prevent PGCs from dividing in starved animals and to maintain germ cell viability...
Journal Articles
Journal: Development
Development (1999) 126 (15): 3275–3283.
Published: 1 August 1999
... PIE-1 MES-2 MES-6 transcriptional repression P granules germline Caenorhabditis elegans The mechanisms that set the germline apart from the soma have fascinated biologists since the work of Weismann in the late 1800s ( Weismann, 1893 ). Several developmental characteristics distinguish...
Journal Articles
Journal Articles
Journal: Development
Development (1996) 122 (4): 1303–1312.
Published: 1 April 1996
...Steven N. Hird; Janet E. Paulsen; Susan Strome ABSTRACT Germ granules are ribonucleoprotein particles that are thought to function in germline specification in invertebrates and possibly in vertebrates. In Caenorhabditis elegans , these structures, termed P granules, are partitioned to the germline...
Journal Articles
Journal: Development
Development (1994) 120 (10): 2823–2834.
Published: 1 October 1994
... with the germlinespecific P granules. We observed embryonically transcribed RNAs in somatic cells as early as the 4-cell stage. These transcripts were not detected in germline cells. These observations suggest that mechanisms which distinguish between soma and germline cause asymmetries in mRNA stability and transcription...