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Keywords: Ovary
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Journal Articles
Journal: Development
Development (2023) 150 (17): dev201717.
Published: 11 September 2023
... the morphology of the adult organs. In the ovary, Chsy mutants exhibited altered stiffness of the basement membrane and muscle dysfunction, leading to a gradual degradation of the gross organ structure as mutant animals aged. Our observations show that normal CS function is required for the maintenance...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (18): dev200889.
Published: 15 September 2022
... approach to quantify stigma and ovary morphology. We demonstrate the suitability of the approach, which uses light-microscopy imaging and machine learning, for the analysis of floral organ traits in field-grown plants using fresh and fixed samples. We show that the unpollinated carpel undergoes a well...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 5 December 2018
... investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the Drosophila ovary, but must be downregulated in cells that have exited the niche to allow for differentiation. We found that Wingless produced by inner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev163394.
Published: 25 April 2018
...Andrew W. Allbee; Diego E. Rincon-Limas; Benoît Biteau ABSTRACT The Drosophila ovary serves as a model for pioneering studies of stem cell niches, with defined cell types and signaling pathways supporting both germline and somatic stem cells. The establishment of the niche units begins during...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 1 March 2016
...-of-function phenotype, but we find no apparent phenotypes upon removal of let-7 in the adult ovary or testis. Our finding that chinmo is necessary and sufficient to promote a male identity in adult gonadal somatic cells suggests that the sexual identity of somatic cells can be reprogrammed in the adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2554–2563.
Published: 1 August 2015
...Kathryn J. Grive; Richard N. Freiman The adult mammalian ovary is devoid of definitive germline stem cells. As such, female reproductive senescence largely results from the depletion of a finite ovarian follicle pool that is produced during embryonic development. Remarkably, the crucial nature...
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 1 March 2015
...Tamar Lengil; Dana Gancz; Lilach Gilboa How the numbers of niches and resident stem cells within a particular organ are determined during development and how they may be modulated or corrected is a question with significant medical implications. In the larval ovary of Drosophila melanogaster...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (16): 3159–3164.
Published: 15 August 2014
... regulator of the ERα signaling axis. Unexpectedly, examination of the ovaries of targeted mice revealed significantly increased numbers of secondary and antral follicles, and reduced Id4 expression in the granulosa cells. Moreover, expression of the cascade of enzymes that are crucial for estrogen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4490–4498.
Published: 15 November 2013
...Pankaj Sahai-Hernandez; Todd G. Nystul Epithelial stem cells are maintained within niches that promote self-renewal by providing signals that specify the stem cell fate. In the Drosophila ovary, epithelial follicle stem cells (FSCs) reside in niches at the anterior tip of the tissue and support...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4145–4154.
Published: 15 October 2013
... interactions coordinate homeostasis and growth in the Drosophila gonad . Nature 443 , 97 – 100 . Gilboa L. , Lehmann R. ( 2007 ). Changing places: a novel type of niche and stem cell coordination in the Drosophila ovary . Cell Stem Cell 1 , 239 – 240 . Goberdhan D. C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3819–3825.
Published: 15 September 2013
... known as the nuage. In this study, we surveyed mouse ovaries and found, for the first time, transient appearance of nuage-like structures in oocytes of primordial follicles. Mouse vasa homolog (MVH), Piwi-like 2 (PIWIL2/MILI) and tudor domain-containing 9 (TDRD9) are present in these structures, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 4029–4039.
Published: 1 November 2012
... such as macrophages. However, in some tissues with limited accessibility to circulating cells, engulfment is carried out by neighboring non-professional phagocytes such as epithelial cells. Here, we investigate the mechanism of corpse clearance in the Drosophila melanogaster ovary, a tissue that is closed...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (24): 4123–4132.
Published: 15 December 2009
... / Df ( 3L ) BSC2 flies. Ovaries dissected from adult flies were fixed and stained using standard protocols. We raised three antibodies directed against different parts of Fat2. All three antibodies, however, failed to give specific immunostainings in ovaries (data not shown). To generate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2177–2186.
Published: 1 July 2009
...Cynthia Vied; Daniel Kalderon Normal self-renewal of follicle stem cells (FSCs) in the Drosophila ovary requires Hedgehog (Hh) signaling. Excess Hh signaling, induced by loss of patched ( ptc ), causes cell-autonomous duplication of FSCs. We have used a genetic screen to identify Mastermind (Mam...
Includes: Supplementary data