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Keywords: Ovary
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (18): dev194886.
Published: 25 September 2020
... by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Zebrafish Nedd8 plays an important role in controlling ovarian maturation through suppressing androgen receptor activity. Nedd8 Zebrafish Androgen receptor Ovary Testis Neddylation Total RNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 05 December 2018
... investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the Drosophila ovary, but must be downregulated in cells that have exited the niche to allow for differentiation. We found that Wingless produced by inner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev163394.
Published: 25 April 2018
...Andrew W. Allbee; Diego E. Rincon-Limas; Benoît Biteau ABSTRACT The Drosophila ovary serves as a model for pioneering studies of stem cell niches, with defined cell types and signaling pathways supporting both germline and somatic stem cells. The establishment of the niche units begins during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4631–4642.
Published: 15 December 2016
...Michael J. Johnston; Shaked Bar-Cohen; Ze'ev Paroush; Todd G. Nystul In the epithelial follicle stem cells (FSCs) of the Drosophila ovary, Epidermal Growth Factor Receptor (EGFR) signaling promotes self-renewal, whereas Notch signaling promotes differentiation of the prefollicle cell (pFC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 01 March 2016
...-of-function phenotype, but we find no apparent phenotypes upon removal of let-7 in the adult ovary or testis. Our finding that chinmo is necessary and sufficient to promote a male identity in adult gonadal somatic cells suggests that the sexual identity of somatic cells can be reprogrammed in the adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2554–2563.
Published: 01 August 2015
...Kathryn J. Grive; Richard N. Freiman The adult mammalian ovary is devoid of definitive germline stem cells. As such, female reproductive senescence largely results from the depletion of a finite ovarian follicle pool that is produced during embryonic development. Remarkably, the crucial nature...
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 01 March 2015
...Tamar Lengil; Dana Gancz; Lilach Gilboa How the numbers of niches and resident stem cells within a particular organ are determined during development and how they may be modulated or corrected is a question with significant medical implications. In the larval ovary of Drosophila melanogaster...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 681–691.
Published: 15 February 2015
... content but normalizes PTX3 protein production. Highlighted article : In mice, obesity induces oocyte mitochondrial dysfunction that is transmitted to offspring but that can be reversed using interventions prior to conception. BGP-15 ER stress Mitochondria mtDNA Obesity Ovary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 82–91.
Published: 01 January 2015
...Stephanie Vlachos; Sharayu Jangam; Ryan Conder; Michael Chou; Todd Nystul; Nicholas Harden In the germarium of the Drosophila ovary, germline cysts are encapsulated one at a time by a follicular epithelium derived from two follicle stem cells (FSCs). Ovaries in flies mutant for the serine/threonine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3159–3164.
Published: 15 August 2014
... regulator of the ERα signaling axis. Unexpectedly, examination of the ovaries of targeted mice revealed significantly increased numbers of secondary and antral follicles, and reduced Id4 expression in the granulosa cells. Moreover, expression of the cascade of enzymes that are crucial for estrogen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4490–4498.
Published: 15 November 2013
...Pankaj Sahai-Hernandez; Todd G. Nystul Epithelial stem cells are maintained within niches that promote self-renewal by providing signals that specify the stem cell fate. In the Drosophila ovary, epithelial follicle stem cells (FSCs) reside in niches at the anterior tip of the tissue and support...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4145–4154.
Published: 15 October 2013
... statement The authors declare no competing financial interests. 2 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Stem cells Ovary Drosophila Nutrition InR Germ cells Stem cell units, which are composed of stem cells and their supportive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3819–3825.
Published: 15 September 2013
... known as the nuage. In this study, we surveyed mouse ovaries and found, for the first time, transient appearance of nuage-like structures in oocytes of primordial follicles. Mouse vasa homolog (MVH), Piwi-like 2 (PIWIL2/MILI) and tudor domain-containing 9 (TDRD9) are present in these structures, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 4029–4039.
Published: 01 November 2012
... such as macrophages. However, in some tissues with limited accessibility to circulating cells, engulfment is carried out by neighboring non-professional phagocytes such as epithelial cells. Here, we investigate the mechanism of corpse clearance in the Drosophila melanogaster ovary, a tissue that is closed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2519–2526.
Published: 01 August 2010
... ) Competing interests statement 18 5 2010 © 2010. To examine the role of DM-W in ovary formation in X. laevis , we tried to perform a loss-of-function analysis of DM-W in ZW individuals using RNA interference (RNAi). Li and Rohrer ( Li and Rohrer, 2006 ) have reported transgenic-based...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4123–4132.
Published: 15 December 2009
... of Physiological Chemistry, Medical Theoretical Center, Dresden University of Technology, Germany † Author for correspondence ( dahmann@mpi-cbg.de ) 8 10 2009 © 2009. 2009 Drosophila Ovary Follicle cell Cadherin Fat2 Planar cell polarity The polarization of cells within...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2177–2186.
Published: 01 July 2009
...Cynthia Vied; Daniel Kalderon Normal self-renewal of follicle stem cells (FSCs) in the Drosophila ovary requires Hedgehog (Hh) signaling. Excess Hh signaling, induced by loss of patched ( ptc ), causes cell-autonomous duplication of FSCs. We have used a genetic screen to identify Mastermind (Mam...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3731–3743.
Published: 15 November 2008
... of female mice is profoundly affected by the loss of GATA4-FOG2 interaction. We have also identified the Dkk1 gene, which encodes a secreted inhibitor of canonical β-catenin signaling, as a target of GATA4-FOG2 repression in the developing ovary. The tissue-specific ablation of theβ-catenin gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2127–2137.
Published: 15 June 2008
... failure. The mutant ovaries contained numerous abnormal follicle-like structures that were devoid of mitotic and apoptotic cells and cells expressing granulosa cell-specific marker genes. Follicles that proceeded to the antral stage failed to ovulate and expressed reduced levels of ovulation-related genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (4): 677–685.
Published: 15 February 2008
... ovary. A possible role for estrogen in this asymmetric ovarian development has been proposed in the chick, but the mechanism underlying this process is largely unknown. Here, we identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive...
Includes: Supplementary data