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Keywords: Outflow tract
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Journal Articles
Journal: Development
Development (2020) 147 (17): dev185249.
Published: 11 September 2020
... SHF progenitor pool leads to an underdeveloped right ventricle (RV) and outflow tract (OFT). In its most severe form, there is severe RV hypoplasia and poorly developed OFT resulting in early embryonic lethality. In its milder form, the OFT is foreshortened and misaligned, resulting in a double outlet...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev185900.
Published: 17 June 2020
..., contractility and blood flow generate biomechanical cues that influence patterns of cell behavior. Here, we address the interplay between function and form during the assembly of the cardiac outflow tract (OFT), a crucial connection between the heart and vasculature that develops while circulation is under way...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev185652.
Published: 02 March 2020
... later-differentiating outflow tract (OFT). We show that improper specification and proliferation of second heart field (SHF) progenitors in zebrafish lazarus ( lzr ) mutants, which lack the transcription factor Pbx4, produces enlarged hearts owing to an increase in ventricular and smooth muscle cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4616–4624.
Published: 15 December 2017
... outflow tract (OFT). In zebrafish, previous lineage-tracing and mutant analyses suggested that SHF ventricular and OFT progenitors co-migrate to the arterial pole of the zebrafish heart tube soon after their specification in the nkx2.5 + field of anterior lateral plate mesoderm (ALPM). Using additional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 1041–1054.
Published: 15 March 2016
... spatiotemporal inhibition of Wnt/β-catenin signaling by chemically inducible overexpression of Dkk1. Unexpectedly, this approach indicates canonical Wnt signaling is required for EMT in the proximal outflow tract (pOFT) but not atrioventricular canal (AVC) cushions. Furthermore, Wnt indirectly promotes pOFT EMT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3395–3402.
Published: 15 August 2013
...Yan Bai; Jun Wang; Yuka Morikawa; Margarita Bonilla-Claudio; Elzbieta Klysik; James F. Martin Congenital heart disease (CHD) is a devastating anomaly that affects ∼1% of live births. Defects of the outflow tract (OFT) make up a large percentage of human CHD. We investigated Bmp signaling in mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 2025–2034.
Published: 15 May 2011
... ventricle and the outflow tract are derived from an adjacent population of precursors known as the second heart field. In addition, the cardiac neural crest contributes cells to the septum of the outflow tract to separate the systemic and the pulmonary circulations. The amphibian heart has a single...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3599–3610.
Published: 01 November 2008
... inactivation of Fgfr1 and Fgfr2 and overexpression of the FGF antagonist sprouty 2 in different cell types, we have dissected the role of FGF signaling during heart outflow tract development in mouse. Contrary to expectation, cardiac neural crest and endothelial cells are not primary paracrine targets. FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (8): 1593–1604.
Published: 15 April 2007
...Matthew M. Goddeeris; Robert Schwartz; John Klingensmith; Erik N. Meyers Cardiac outflow tract (OFT) septation is crucial to the formation of the aortic and pulmonary arteries. Defects in the formation of the OFT can result in serious congenital heart defects. Two cell populations, the anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4595–4606.
Published: 15 November 2006
... -expressing cells, brings about a significant extension of the heart tube and extraneous looping caused by the elevated proliferation of cardioblasts in the distal outflow tract. This activity is independent of the further recruitment of extracardiac cells from the secondary heart field and permissive for the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (12): 2419–2433.
Published: 15 June 2006
..., the pathogenesis of complex cardiac and outflow tract defects observed in Fgf8-deficient mice, and the specific source(s) of Fgf8 required for outflow tract formation and subsequent remodeling are unknown. A detailed examination of the timing and location of Fgf8 production revealed previously...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2063–2073.
Published: 15 May 2006
...Shasha Liu; Fangyu Liu; Amanda E. Schneider; Tara St. Amand; Jonathan A. Epstein; David E. Gutstein Connexin 43 (Cx43) is expressed in the embryonic heart, cardiac neural crest (CNC) and neural tube, and germline knockout (KO) of Cx43 results in aberrant cardiac outflow tract (OFT) formation and...
Journal Articles
Journal: Development
Development (2004) 131 (20): 5041–5052.
Published: 15 October 2004
... is expressed in the outflow tract, inner curvature, atrioventricular canal and inflow tract, corresponding to a myocardial zone that is excluded from chamber differentiation at 9.5 days post coitus (dpc). We have used targeted mutagenesis in mice to investigate Tbx2 function. Mice heterozygous for a...
Journal Articles
Journal: Development
Development (2004) 131 (18): 4477–4487.
Published: 15 September 2004
... severe defects in cardiac morphogenesis, including outflow tract septation and cushion defects, a thin ventricular myocardial compact zone caused by defects in myocyte maturation and proliferation, and lack of proper ventricular septation. These defects lead to embryonic death at E14.5 and are similar to...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3367–3379.
Published: 15 July 2004
...Wood Yee Chan; Chui Shan Cheung; Kim Ming Yung; Andrew J. Copp A sub-population of the neural crest is known to play a crucial role in development of the cardiac outflow tract. Studies in avians have mapped the complete migratory pathways taken by `cardiac' neural crest cells en route from the...
Journal Articles
Journal: Development
Development (2004) 131 (13): 3217–3227.
Published: 01 July 2004
...Huansheng Xu; Masae Morishima; John N. Wylie; Robert J. Schwartz; Benoit G. Bruneau; Elizabeth A. Lindsay; Antonio Baldini Dysmorphogenesis of the cardiac outflow tract (OFT) causes many congenital heart defects, including those associated with DiGeorge syndrome. Genetic manipulation in the mouse...
Journal Articles
Journal: Development
Development (2004) 131 (9): 2205–2218.
Published: 01 May 2004
... BMPRIA is unnecessary for many aspects of early neural crest biology. However, mutant embryos display a shortened cardiac outflow tract with defective septation, a process known to require neural crest cells and to be essential for perinatal viability. Surprisingly, these embryos die in mid-gestation...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6361–6374.
Published: 22 December 2003
... with a constellation of heart, outflow tract, great vessel and pharyngeal gland defects that phenocopies human deletion 22q11 syndromes, such as DiGeorge. We postulate that these Fgf8 hypomorphic phenotypes result from disruption of local FGF8 signaling from pharyngeal arch epithelia to mesenchymal...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4591–4603.
Published: 01 October 2002
... for FGF8 during development of pharyngeal arch, pharyngeal pouch and neural crest-derived tissues. We show that FGF8 deficient embryos have lethal malformations of the cardiac outflow tract, great vessels and heart due, at least in part, to failure to form the fourth pharyngeal arch arteries, altered...
Journal Articles
Journal: Development
Development (2002) 129 (3): 733–746.
Published: 01 February 2002
...Steven W. Kubalak; D. Reneé Hutson; Karen K. Scott; Rebecca A. Shannon Septation of the single tubular embryonic outflow tract into two outlet segments in the heart requires the precise integration of proliferation, differentiation and apoptosis during remodeling. Lack of proper coordination...