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Keywords: Otx2
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
... identification of many cis -regulatory modules (CRMs) active in cone/HC RPCs and developing cones. Two transcription factors, Otx2 and Oc1, were found to bind to many of these CRMs, including those near genes important for cone development and function, and their binding sites were required for activity. We also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.199166.
Published: 19 April 2021
... into the germline requires activation of a naïve-like pluripotency gene regulatory network (GRN). Recent work showed that suppression of OTX2 expression in the epiblast by BMP4 allows cells to develop a PGC fate in a precise temporal window. However, the mechanisms by which OTX2 suppresses PGC fate are...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev187922.
Published: 26 July 2020
... cellular contexts. Considering the limited number of TFs in the genome and the tremendous number of events that need to be regulated, re-use of TFs is necessary. We analyzed how the expression of the homeobox TF, orthodenticle homeobox 2 (Otx2), is regulated in a cell type- and stage-specific manner during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev159640.
Published: 12 March 2018
...Yumeko Satou; Kohei Minami; Erina Hosono; Hajime Okada; Yuuri Yasuoka; Takashi Shibano; Toshiaki Tanaka; Masanori Taira ABSTRACT The homeodomain transcription factor Otx2 has essential roles in head and eye formation via the negative and positive regulation of its target genes, but it remains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 1948–1958.
Published: 01 June 2017
... binding regions of five major TFs. Analysis of in vivo biotinylated ZIC2, OTX2, SOX2, POU5F1 and POU3F1 binding in EpiSCs identified several new features. (1) Megabase-scale genomic domains rich in ZIC2 peaks and genes alternate with those rich in POU3F1 but sparse in genes, reflecting the clustering of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3859–3867.
Published: 15 October 2014
...Chi Kin Ip; Nicolas Fossat; Vanessa Jones; Thomas Lamonerie; Patrick P. L. Tam The Otx2 gene encodes a paired-type homeobox transcription factor that is essential for the induction and the patterning of the anterior structures in the mouse embryo. Otx2 knockout embryos fail to form a head. Whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 377–388.
Published: 15 January 2014
... with specialized identity and fate. These events are controlled by signals emitted by organizing centers and interpreted by target progenitors, which activate superimposing waves of intrinsic factors restricting their identity and fate. The transcription factor Otx2 plays a crucial role in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 389–398.
Published: 15 January 2014
... distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Lhx9 Otx2 Gbx2 Isthmo-optic nucleus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 43–55.
Published: 01 January 2013
... considerable advances, the molecular mechanism controlling the ESC state and pluripotency transition from ESCs to EpiSCs have not been fully elucidated. Here we show that Otx2, a transcription factor essential for brain development, plays a crucial role in ESCs and EpiSCs. Otx2 is required to maintain the ESC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 3926–3937.
Published: 01 November 2012
... epiblast state and ANP development depending on their balance. Analyses of the effects of knockdown and overexpression of these factors in EpiSCs on the levels of downstream transcription factors identified the following regulatory functions: cross-regulation among Zic, Otx2, Sox2 and Pou factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 725–734.
Published: 15 February 2011
...N. Abimbola Sunmonu; Kairong Li; Qiuxia Guo; James Y. H. Li In vertebrates, the common expression border of two homeobox genes, Otx2 and Gbx2 , demarcates the prospective midbrain-hindbrain border (MHB) in the neural plate at the end of gastrulation. The presence of a compartment boundary at the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (19): 3311–3322.
Published: 01 October 2009
...Zsuzsa Agoston; Dorothea Schulte The transcription factor Otx2 is expressed throughout the anterior neuroectoderm and is required for the formation of all forebrain- and midbrain-derived structures. The molecular determinants that cooperate with Otx2 to subdivide its expression domain into distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (15): 2545–2555.
Published: 01 August 2009
.... We show that Otx2 provides the crucial anterior-posterior positional information for the generation of red nucleus neurons in the murine midbrain. Moreover, the homeodomain transcription factor Nkx6-1 controls the proper development of the red nucleus and of the oculomotor and trochlear nucleus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3459–3470.
Published: 15 October 2008
... (PD). Prospective cell transplantation therapies for PD require full knowledge of the developmental pathways that control mdDA neurogenesis. We have previously shown that Otx2 is required for the establishment of the mesencephalic field and molecular code of the entire ventral mesencephalon (VM). Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4243–4253.
Published: 01 December 2007
...@cchmc.org ) 11 9 2007 © 2007. 2007 Prox1 Gfi1 Otx2 Opsin Cell-specific gene expression Photoreceptor cell Drosophila photoreceptor cells (PRs) constitute a unique system for studying how neuronal diversity is achieved during sensory system development. The fly compound eye...
Journal Articles
Journal: Development
Development (2007) 134 (17): 3213–3225.
Published: 01 September 2007
... neurogenic activity and generate mesDA neurons in vitro. By contrast, sorted caudal FP cells have no neurogenic potential, as previously thought. Analysis of dreher mutant mice carrying a mutation in the Lmx1a locus and transgenic mice ectopically expressing Otx2 in caudal FP cells demonstrated that Otx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (10): 1891–1900.
Published: 15 May 2006
... Otx2 Isthmic organiser Following neural induction, local organisers act within the neural plate to refine local identities along the anteroposterior axis( Echevarria et al., 2003 ; Jessell and Sanes, 2000 ; Lumsden and Krumlauf, 1996 ). Understanding how these organisers influence their...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 89–98.
Published: 01 January 2006
... in close vicinity to developing midbrain dopaminergic neurons. Here, we show that Wnt1 regulates the genetic network, including Otx2 and Nkx2-2, that is required for the establishment of the midbrain dopaminergic progenitor domain during embryonic development. In addition, Wnt1 is required for the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3209–3216.
Published: 15 July 2005
... ) 13 5 2005 ©2005. 2005 Midbrain-hindbrain boundary Isthmic organizer Lineage restriction Neuromeres segments Zebrafish Mesencephalon Metencephalon otx2 gbx1 fgf8 The developing central nervous system is compartmentalized at the neural tube stage into discrete...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2309–2318.
Published: 15 May 2005
...Zhengshi Lin; Raquel Cantos; Maria Patente; Doris K. Wu Gbx2 is a homeobox-containing transcription factor that is related to unplugged in Drosophila. In mice, Gbx2 and Otx2 negatively regulate each other to establish the mid-hindbrain boundary in the neural tube. Here, we show that Gbx2 is...