... and the transcription factor Otx are required for the expression of Fer2 in the dopaminergic cell lineage. Our findings establish the cellular and molecular framework for fully understanding the commitment to dopaminergic cells in the simple chordate brain. * Author for correspondence ( [email protected]...

... of ectopic pineal progenitors. We also demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the non-neural border by repressing pineal fate and that the Otx transcription factors promote pinealogenesis by inhibiting this FGF activity. The non-neural origin...

... studies show that Otx2 is essential for spatial restriction of the sensory domain in the mammalian cochlea. Inner ear Cochlea Otx Myc Organ of Corti Mouse Otx2 , a murine ortholog of the Drosophila orthodenticle ( otd ; ocelliless – FlyBase) gene, encodes a transcription factor...

... conserved among tetrapods and unexpectedly directed all the Emx2 expression in forebrain: caudal forebrain primordium at E8.5, dorsal telencephalon at E9.5-E10.5 and the cortical ventricular zone after E12.5. Otx, Tcf, Smad and two unknown transcription factor binding sites were essential to all...

... , the ceh-36 Otx homeobox gene is expressed in the AWC sensory neurons throughout postembryonic development, and regulates terminal differentiation of this neuronal subtype. Here, we show that the HMX/NKX homeodomain protein MLS-2 regulates ceh-36 expression specifically in the AWC neurons. Consequently...

... for correspondence (e-mail: [email protected] ) 1 2 2006 © 2006. 2006 Lamprey Zebrafish Agnathan Gnathostome Inner ear Otic vesicle Macula follistatin ptc otx Evolution Placode Hair cell Planar polarity pattern The vertebrate inner...

... show no detectable sequence conservation in the non-coding regions of studied orthologous genes. To address how a common developmental program can be maintained without detectable cis - regulatory sequence conservation, we compared in both species the regulation of Otx , a gene with a shared complex...

... and an intervening midbrain/hindbrain boundary region, which are characterized by the specific expression of the Otx, Hox and Pax2/5/8 genes, respectively. We show that the embryonic brain of the fruitfly Drosophila melanogaster expresses all three sets of homologous genes in a similar tripartite pattern. Thus...

... using XOtx2 or XOtx5b probes to identify the cell types expressing these otd/Otx family members( Fig. 3 ). We found that messenger RNA from both of these genes is expressed in bipolar cells( Fig. 3A-F ). Of the GFP-labelled bipolar cells 55%±8% were co-labelled with XOtx5b , while 82%±5% were...

... underlying the known dependence of oral-aboral ectoderm polarity on intercellular signaling. *Author for correspondence (e-mail: [email protected] ) 13 8 2001 © 2001. 2001 Morpholino Transcriptional repressor Embryonic axes Otx β-catenin Sea urchin Patterning...

... of midbrain/hindbrain development, yet relatively little is known about forebrain organization. Nested expression among Otx and Emx genes has implicated their roles in rostral brain regionalization, but single mutant phenotypes of these genes have not provided sufficient information. In order to genetically...