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Keywords: Otx
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (12): dev198754.
Published: 14 June 2021
... and the transcription factor Otx are required for the expression of Fer2 in the dopaminergic cell lineage. Our findings establish the cellular and molecular framework for fully understanding the commitment to dopaminergic cells in the simple chordate brain. In contrast to the mammalian midbrain, the Otx-Fer2-Th...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev171405.
Published: 21 November 2019
... of ectopic pineal progenitors. We also demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the non-neural border by repressing pineal fate and that the Otx transcription factors promote pinealogenesis by inhibiting this FGF activity. The non-neural origin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2792–2800.
Published: 15 August 2015
... by The Company of Biologists Ltd 2015 Summary: A microarray-based screen identifies Otx2 as a crucial target of N-myc, and further studies show that Otx2 is essential for spatial restriction of the sensory domain in the mammalian cochlea. Inner ear Cochlea Otx Myc Organ of Corti Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2939–2949.
Published: 1 September 2010
... conserved among tetrapods and unexpectedly directed all the Emx2 expression in forebrain: caudal forebrain primordium at E8.5, dorsal telencephalon at E9.5-E10.5 and the cortical ventricular zone after E12.5. Otx, Tcf, Smad and two unknown transcription factor binding sites were essential to all...
Journal Articles
Journal: Development
Development (2010) 137 (6): 963–974.
Published: 15 March 2010
... , the ceh-36 Otx homeobox gene is expressed in the AWC sensory neurons throughout postembryonic development, and regulates terminal differentiation of this neuronal subtype. Here, we show that the HMX/NKX homeodomain protein MLS-2 regulates ceh-36 expression specifically in the AWC neurons. Consequently...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (7): 1347–1357.
Published: 1 April 2006
... for Otx1 in the inner ear has previously been implicated in the evolution of the horizontal semicircular canal and crista in the gnathostome lineage ( Mazan et al.,2000 ). Although the lamprey possesses an otx gene, it is not expressed in the developing ear, which lacks these structures( Ueki et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (7): 1663–1674.
Published: 1 April 2005
... show no detectable sequence conservation in the non-coding regions of studied orthologous genes. To address how a common developmental program can be maintained without detectable cis - regulatory sequence conservation, we compared in both species the regulation of Otx , a gene with a shared complex...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (11): 2365–2373.
Published: 1 June 2003
... and an intervening midbrain/hindbrain boundary region, which are characterized by the specific expression of the Otx, Hox and Pax2/5/8 genes, respectively. We show that the embryonic brain of the fruitfly Drosophila melanogaster expresses all three sets of homologous genes in a similar tripartite pattern. Thus...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1281–1294.
Published: 1 April 2003
... Otx XOtx2 XOtx5 XOtx5b Bipolar cell Photoreceptor VP16 Engrailed Xenopus laevis Opsin Lipofection Rod photoreceptors and bipolars are among the last cells to be born and differentiate from the late-progenitor pool( Carter-Dawson and LaVail,1979 ; Chang and Harris,1998 ; Holt et...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4393–4404.
Published: 15 November 2001
... embryos, accumulation of aboral ectoderm-specific markers is strongly suppressed ( Li et al., 1999 ). Because Otx and Gsc have been shown to bind to the same cis -acting elements in other systems ( Mailhos et al., 1998 ), it is likely that SpGsc can compete for binding at SpOtx target genes in oral...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2433–2450.
Published: 1 July 2001
... of midbrain/hindbrain development, yet relatively little is known about forebrain organization. Nested expression among Otx and Emx genes has implicated their roles in rostral brain regionalization, but single mutant phenotypes of these genes have not provided sufficient information. In order to genetically...