... for formation of ectodermal domains at neural plate stages. In addition, altering Sobp levels disrupts otic vesicle development and causes craniofacial cartilage defects. Expression of Xenopus Sobp containing the human variant disrupts the pre-placodal ectoderm similar to full-length Sobp, but other changes...

... and implicate another T-box factor, TBX1, as a crucial mediator in this regulatory network. Summary: TBX2 is required to locally restrict otic neurogenesis by repression of FGF signalling and maintenance of TBX1, and TBX2 and TBX3 control patterning in other domains of the otocyst. Otic vesicle...

...Victor Muthu; Alex M. Rohacek; Yao Yao; Staci M. Rakowiecki; Alexander S. Brown; Ying-Tao Zhao; James Meyers; Kyoung-Jae Won; Shweta Ramdas; Christopher D. Brown; Kevin A. Peterson; Douglas J. Epstein ABSTRACT The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response...

... the otic vesicle lumen, become tethered to the tips of hair cell kinocilia (tether cilia) at the otic vesicle poles, forming two otoliths. We have used high-speed video microscopy to investigate the role of cilia and ciliary motility in otolith formation. In wild-type ears, groups of motile cilia...

...Alexander S. Brown; Douglas J. Epstein In mouse embryos lacking sonic hedgehog (Shh), dorsoventral polarity within the otic vesicle is disrupted. Consequently, ventral otic derivatives, including the cochlear duct and saccule, fail to form, and dorsal otic derivatives, including the semicircular...

... somite (early otic vesicle) stages. We now show that Fgf signalling is both necessary and sufficient for anterior otic specification during a similar period, a function that is completely separable from its earlier role in otic placode induction. In lia –/– ( fgf3 –/– ) mutants, anterior otic character...

.... Transplantation experiments suggest that the effects of the loss of Hh pathway inhibition on the ear are mediated directly. These new data suggest that Hh signalling must be kept tightly repressed for the correct acquisition of dorsolateral cell fates in the zebrafish otic vesicle, revealing distinct similarities...

... with dilated cardiomyopathy, we studied eya4 expression during zebrafish development and characterized eya4 deficiency. eya4 morphant fish embryos had reduced numbers of hair cells in the otic vesicle and lateral line neuromasts with impaired sensory responses. Analyses of candidate genes that are known...

... inner ear is not reflected in its early development; the lamprey otic vesicle is highly asymmetric about the anteroposterior axis, both morphologically and molecularly, and bears a striking resemblance to the zebrafish otic vesicle. The single sensory macula originates as two foci of hair cells...

... development Otic vesicle Mouse The mammalian inner ear develops from a thickening of the ectoderm adjacent to the hindbrain known as the otic placode, which invaginates to form the otocyst. The teardrop-shaped otocyst then undergoes a series of morphogenetic events to give rise to a structurally...

... of the Pax-Six-Eya-Dach gene network to control organ development. Six1 is expressed in otic vesicles, nasal epithelia,branchial arches/pouches, nephrogenic cords, somites and a limited set of ganglia. In this study, we established Six1 -deficient mice and found that development of the inner ear, nose...

... recombination results in severe developmental defects during differentiation of the otic vesicle. We have addressed the precise roles of FGF3 and other FGF family members during formation of the murine inner ear using both loss- and gain-of-function experiments. We generated a new mutant allele lacking...

... evidence that Hedgehog signalling from ventral midline structures acts directly on the zebrafish otic vesicle to induce posterior otic identity. We demonstrate that two strong Hedgehog pathway mutants, chameleon ( con tf18b ) and slow muscle omitted ( smu b641 ) exhibit a striking partial mirror image...

...-hamburg.de ) 18 02 2000 18 04 2000 © 2000 by Company of Biologists 2000 Otic placode Otic vesicle Fibroblast growth factor HSV-1 Ectopic expression Chicken The head ectoderm of vertebrates develops three pairs of sensory placodes, nose, lens and inner ear from anterior...

...Thorsten Hadrys; Thomas Braun; Silke Rinkwitz-Brandt; Hans-Henning Arnold; Eva Bober ABSTRACT The inner ear develops from the otic vesicle, a one-cell-thick epithelium, which eventually transforms into highly complex structures including the sensory organs for balance (vestibulum) and hearing...

... phenotype; these fall into several phenotypic classes, affecting presence or size of the otoliths, size and shape of the otic vesicle and formation of the semicircular canals, and define at least 20 complementation groups. Mutations in seven genes cause loss of one or both otoliths, but do not appear...

... in the differentiation of these epithelial cell types. * Author for correspondence © 1991 by Company of Biologists 1991 nerve growth factor (NGF) receptor otic vesicle otocyst cochleovestibular ganglion in situ hybridization chick embryo rat embryo immunocytochemistry carbocyanine tracers...

.... The overall direction of growth was reversed by RA and the ratio of the internal to the external vesicular surface area increased with RA concentration. The expression of the nuclear protooncogene c-fos in the developing otic vesicle was transient and stage-dependent. High levels of c-fos mRNA were positively...

.... In the eye, Pax2 expression is restricted to the ventral half of the optic cup and stalk and later to the optic disc and nerve. In the ear, expression is restricted to regions of the otic vesicle that form neuronal components. The transient and restricted nature of Pax2 expression suggests that this murine...

... pairs of rhombomeres (R4+R5, R2+R3) starts in R4, immediately followed by R2. The caudal rhombomeres of both pairs are delayed (R5, R3). Then the postotic rhombomere is subdivided, whereby R7 differentiates before R6. Thus, the development in the direct vicinity of the otic vesicle is delayed (R5, R6...