... provided that the original work is properly attributed. Highlighted Article: The identification of previously unknown Six1 targets, the molecular mechanisms that mediate Six1 function in the developing ear and potential candidates for human congenital deafness. Ear development Otic placode...

... to promoter regions of actively transcribed genes to control H3K9 demethylation. Chick embryo Epigenetic marks Histone modification Otic placode Transcription factor Biotechnology and Biological Sciences Research Council 10.13039/501100000268 BB/I021647/1 BB/M006964 National...

... – are orchestrated by gradients of signaling molecules. * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. 2012 Otic placode Morphogen Inner ear Cochlea Otocyst...

...Chathurani S. Jayasena; Takahiro Ohyama; Neil Segil; Andrew K. Groves The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2 + ectoderm gives rise not only to the otic placode but also to the surrounding cranial...

[email protected] ) 30 4 2007 © 2007. 2007 Competence dlx3b Danio rerio fgf3 fgf8 foxi1 Inner ear Morpholino Otic induction Otic placode Retinoic acid Zebrafish The vertebrate inner ear is the sensory organ that provides auditory and vestibular functions. It develops...

... (arrows in G,I). A, anterior; D, Dorsal. For a first indication of the effect of DAPT on the development of prosensory patches in the otic epithelium, we examined the expression of Serrate1 . In the chick embryo, the otic placode forms immediately anterior to the first somite and becomes...

... identified that mark such a`pre-placodal' domain. However, the functional significance of this pre-placodal domain is still unclear. In the present study, we show that Fgf signaling is necessary and sufficient to directly induce some, but not all,markers of the otic placode in ectoderm taken from the pre...

...Takahiro Ohyama; Othman A. Mohamed; Makoto M. Taketo; Daniel Dufort; Andrew K. Groves The otic placode, the anlagen of the inner ear, develops from an ectodermal field characterized by expression of the transcription factor Pax2 . Previous fate mapping studies suggest that these Pax2 + cells...

[email protected] ) * These authors contributed equally to this work 17 11 2004 ©2005. 2005 Preplacodal domain Otic placode Genetic network Paired Fibroblast growth factor forkhead distal-less msxC Pax proteins are key regulators of developmental processes including...

...Stefan Hans; Dong Liu; Monte Westerfield The vertebrate inner ear arises from an ectodermal thickening, the otic placode, that forms adjacent to the presumptive hindbrain. Previous studies have suggested that competent ectodermal cells respond to Fgf signals from adjacent tissues and express two...

...Natasha Saint-Germain; Young-Hoon Lee; Yanhui Zhang; Thomas D. Sargent; Jean-Pierre Saint-Jeannet The vertebrate inner ear develops from a thickening of the embryonic ectoderm, adjacent to the hindbrain, known as the otic placode. All components of the inner ear derive from the embryonic otic...

...Robert M. Nissen; Jizhou Yan; Adam Amsterdam; Nancy Hopkins; Shawn M. Burgess We identified four insertional alleles of foxi one ( foo ),an embryonic lethal mutation in zebrafish that displays defects in both otic placode and the jaw. In foo/foo embryos the otic placode is split into two smaller...

...Keely S. Solomon; Tetsuhiro Kudoh; Igor B. Dawid; Andreas Fritz The otic placode is a transient embryonic structure that gives rise to the inner ear. Although inductive signals for otic placode formation have been characterized, less is known about the molecules that respond to these signals within...

... in concert and their importance in placode formation is only revealed by inactivating both paralogs. *Author for correspondence (e-mail: [email protected] ) 10 4 2002 © 2002. 2002 Zebrafish dlx3 dlx7 Otic placode Olfactory placode The vertebrate ear and nose...

... of the inner ear, the otic placode. Pax-2, Sox- 3, BMP-7 and Notch are all expressed in placodal ectoderm from the 4-5 somite stage (ss) onwards, well before the otic placode becomes morphologically visible at the 12-14ss. We have used these four molecular markers to show that cranial ectoderm becomes...

... is implicated in induction of the otic placode, we next analysed the expression of genes expressed in early otic placodes, including cPax -2, HNK-1, cek-8, lmx-1, cNkx5-1 and TuJ1 ( Nieto et al., 1992 ; Rinkwitz-Brandt et al., 1996 ; Meyer zum Gottesberge and Mai, 1997 ; Giraldez, 1998 ; Herbrand et al...

... in structures that are probably homologous – support cells of the eye, nephridium, thyroid-like structures and pharyngeal gill slits; although AmphiPax2/5/8 is not transcribed in any structures that could be interpreted as homologues of vertebrate otic placodes or otic vesicles. In sum, the developmental...

...Thomas R. Van De Water ABSTRACT Statoacoustic ganglion neurones (SAG) are produced by the same group of cells (otic placode) that produce all of the receptor ceils that populate the sensory areas of the inner ear. The observation that ingrowth of SAG neurites to presumptive sensory areas...