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Keywords: Otic induction
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Journal Articles
Journal: Development
Development (2007) 134 (13): 2449–2458.
Published: 1 July 2007
..., loss of RA signaling does not affect foxi1 expression or otic competence, but instead results in delayed onset of fgf3 expression and impaired otic induction. fgf8 mutants depleted of RA signaling produce few otic cells, and these cells fail to form a vesicle, indicating that Fgf8 is the primary factor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (4): 923–931.
Published: 15 February 2004
..., is necessary and sufficient for otic induction. However, an alternative model proposes that Fgf must cooperate with Wnt8 to induce otic differentiation. Using a genetic approach in zebrafish, we tested the roles of Fgf3, Fgf8 and Wnt8. We demonstrate that localized misexpression of either Fgf3 or Fgf8...