... to the native tissue. Hair cells Hearing loss Human inner ear organoids Otic Single-cell RNA-seq Ministerio de Ciencia, Innovación y Universidades PRE2021-097774 PID2020-117662GB-I00 Agencia Estatal de Investigación The inner ear is a sensory organ required...

... and Pax8 modulate commitment and behavior in cells that eventually contribute to the otic vesicle and epibranchial placodes. Initially, a subset of epibranchial placode precursors lie lateral to otic precursors within a single Pax2a/8-positive domain; these cells subsequently move to segregate...

...Dan Zou; Derek Silvius; Bernd Fritzsch; Pin-Xian Xu Eya1 encodes a transcriptional co-activator and is expressed in cranial sensory placodes. It interacts with and functions upstream of the homeobox gene Six1 during otic placodal development. Here, we have examined their role in cranial sensory...

... arising from the underlying mesoderm and adjacent neurectoderm. In mice, Fgf3 is expressed in the neurectoderm prior to and concomitant with placode induction and otic vesicle formation,but its absence affects only the later stages of otic vesicle morphogenesis. We show here that mouse Fgf10 is expressed...

... parts of the neural plate. Dlx3 expression in the anterior neural ridge probably correlates to later expression in the olfactory placode. Several of the Dlx genes ( Dlx2 , Dlx3 , Dlx5 and Dlx6 ) are also expressed in the otic placode, and later regionally expressed in the otic vesicle ( Depew et...