... diseases such as osteoporosis. In mammals, receptor activator of NF-κB ligand (Rankl) is a regulator of osteoclast formation and activation: its misexpression causes osteoclast stimulation and osteoporotic bone loss. Here, we report an osteoporotic phenotype that is induced by overexpression of Rankl...

... phenotype in adults. Together, we propose that Lrp6 is one of the key genetic components for the pathogenesis of vertebral segmentation defects and of osteoporosis in humans. ‡ Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work † Present...

... Porter Dr., Palo Alto, CA 94304, USA 08 02 1995 © 1995 by Company of Biologists 1995 osteoporosis astrocytes glycogen store primordial germ cell mouse Heterodimerization of low-affinity LIFR with gp130 is required for the biological activities of LIF and ciliary...