... demonstrates alterations in osteogenic and chondrogenic precursors caused by PDGFRβ D849V . Mutant cells undergo poor osteogenesis in vitro with increased expression of Sox9 and other chondrogenic markers. Mice with PDGFRβ D849V exhibit osteopenia. Increased STAT5 phosphorylation and overexpression of Igf1...

... of NPs, no other peptide hormones that affect remote organs have been identified from the heart. We identified osteocrin (Ostn) as an osteogenesis/chondrogenesis regulatory hormone secreted from CMs in zebrafish. ostn mutant larvae exhibit impaired membranous and chondral bone formation. The impaired...

... bone defects and larval lethality, establishing a key role for Osterix in bone formation in a non-mammalian species. Osteoblasts Osteogenesis Bone modelling Skeleton Medaka Osteoblasts are bone matrix-forming cells that differentiate from Sox9 - and Runx2 -positive mesenchymal...

... for this process. In BAs of Ezh2 cko embryos, high and ectopic expression of the Hox genes mentioned above to suppress osteogenesis and chondrogenesis, as well as of many other Hox genes, is associated with the inhibition of chondrogenic and osteogenic gene expression programs and a virtually complete blockage...

... development and remodeling in the adult, and regulates osteogenesis in a cell-autonomous and non-autonomous manner. * Author for correspondence ( [email protected] ) Author contributions S.N.H. conceived the project, designed, performed and interpreted the experiments, and wrote the paper...

... is completely phenocopied by treating 4 dpf wild-type embryos with either RA or the pharmacological Cyp26 blocker R115866, thus identifying a previously unappreciated role for RA and cyp26b1 in osteogenesis of the vertebral column. Cyp26b1 is expressed within osteoblast cells,demonstrating that RA levels within...

... differentiation of the cranial neural crest. *Author for correspondence (e-mail: [email protected] ) 20 3 2001 © 2001. 2001 Neural crest Culture FGF2 FGFR Chondrogenesis Osteogenesis Skull Quail Cells of the cranial neural crest make a major contribution to the skeletal...

... into preosteoblasts. The differentiation process involves down-regulation of Fgfr2 and exit from the cell cycle, followed by up-regulation of Fgfr1 and (slightly later) up-regulation of the osteogenesis-related genes, including osteopontin . The preosteoblasts begin to secrete matrix and are then defined...

... myogenesis and osteogenesis, indicative of a general block in cellular differentiation. Taken together our data provide evidence for two distinct Notch signaling pathways that function to block differentiation at separate steps during the process of myogenesis in C2C12 myoblasts. Fig. 6. Loss of CBF1...

... the normal paracrine down-regulation of Fgfr2 . * Author for correspondence (e-mail: [email protected] ) 11 07 1997 © 1997 by Company of Biologists 1997 FGF2 FGFR2 osteogenesis cell proliferation skull mouse fetus human There are four fibroblast growth factor...

... functions in others. * Author for correspondence 16 01 1995 © 1995 by Company of Biologists 1995 matrix metalloproteinases mouse embryo embryonic implantation external feature modeling osteogenesis nervous system morphogenesis ECM remodeling Stromelysin-3 (ST3), a new...

... Basel, Switzerland 06 09 1990 © 1990 by Company of Biologists 1990 osteogenesis somatostatin endochondral bone formation Somatostatin is a peptide hormone that acts on many different cell types to inhibit the secretion of hormones, including growth hormone, prolactin...

... extracellular matrix osteogenesis ovary mouse embryo Collagen is the most abundant protein in vertebrates, being the major constituent of connective tissue extracellular matrices in skin, tendon, cartilage and bone. These tissues, and others, are dynamic structures that undergo extensive remodelling...

... of the d-segment into a fibrocartilage responding to androgens after birth ( Fig. 1 ) ( Glucksmann & Cherry, 1972 ; Beresford & Burkart, 1977 ; Beresford & Clayton, 1977 ; Yoshida, Kadota & Fukunishi, 1980 ; Murakami & Mizuno, 1984 a , b ). The chondrogenesis and osteogenesis...