... of bone-forming osteoblasts and bone-resorbing osteoclasts at periosteal and endosteal surfaces, a process we designate trans -pairing. Two types of trans -pairing shift cortical bone in opposite orientations: peri-forming trans -pairing (peri- t -p) increases bone marrow space and endo-forming trans...

... of enriched GO terms in ranked gene lists . BMC Bioinformatics 10 , 48 . 10.1186/1471-2105-10-48 Esen , E. and Long , F. ( 2014 ). Aerobic glycolysis in osteoblasts . Curr. Osteoporos Rep. 12 , 433 - 438 . 10.1007/s11914-014-0235-y Geurtzen , K. , Knopf , F...

...Stephanie C. McMillan; Jing Zhang; Hue-Eileen Phan; Shirine Jeradi; Leona Probst; Matthias Hammerschmidt; Marie-Andrée Akimenko ABSTRACT During zebrafish fin regeneration, blastema cells lining the epidermis differentiate into osteoblasts and joint cells to reconstruct the segmented bony rays. We...

...Benjamin E. Armstrong; Astra Henner; Scott Stewart; Kryn Stankunas Zebrafish innately regenerate amputated fins by mechanisms that expand and precisely position injury-induced progenitor cells to re-form tissue of the original size and pattern. For example, cell signaling networks direct osteoblast...

...Tingsheng Yu; Martin Graf; Joerg Renn; Manfred Schartl; Daria Larionova; Ann Huysseune; Paul Eckhard Witten; Christoph Winkler ABSTRACT osterix ( osx ; sp7 ) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate...

... of the blastema. Chemical interference with Notch signaling resulted in a complete block of regeneration. Notch signaling was not required for the earliest known cellular processes during blastema formation, i.e. dedifferentiation and migration of osteoblasts, but specifically interfered with proliferation...

...Weiguang Wang; Na Lian; Yun Ma; Lingzhen Li; Richard C. Gallant; Florent Elefteriou; Xiangli Yang Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin ( Ocn ) in osteoblasts and indian hedgehog ( Ihh ) in chondrocytes. The relative contribution of Atf4 in chondrocytes...

... of double and triple transgenic larvae, we monitored in vivo formation and activation of osteoclasts, as well as their interaction with osteoblasts. Upon Rankl induction, GFP-positive osteoclasts are first observed in the intervertebral regions and then quickly migrate to the surface of mineralized neural...

...Hong Zhou; Wendy Mak; Robert Kalak; Janine Street; Colette Fong-Yee; Yu Zheng; Colin R. Dunstan; Markus J. Seibel Glucocorticoids are important regulators of bone cell differentiation and mesenchymal lineage commitment. Using a cell-specific approach of osteoblast-targeted transgenic disruption...

... as critical regulators of this process. Here, we show that the homeoprotein engrailed 1(EN1) is expressed during embryonic and perinatal craniofacial bone development, where it localizes to the skeletogenic mesenchyme, and,subsequently, to calvarial osteoblasts and osteoprogenitors. Mice lacking En1 exhibit...