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Keywords: Oskar
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Journal Articles
Journal: Development
Development (2014) 141 (15): 2984–2992.
Published: 01 August 2014
..., which induces a microtubule reorganisation that localises bicoid and oskar mRNAs. Here we show that oocyte polarity requires Slmb, the substrate specificity subunit of the SCF E3 ubiquitin ligase that targets proteins for degradation. The Par-6/aPKC complex is ectopically localised to the posterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 563–573.
Published: 01 February 2014
... poor fecundity. In addition, mutant egg chambers exhibit an arrest at the previtellogenic stage. D-EndoB displayed a crescent localization at the oocyte posterior pole in an Oskar-dependent manner; however, it did not contribute to pole plasm assembly. D-EndoB was found to partially colocalize...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3431–3440.
Published: 15 August 2011
...Kristina S. Sinsimer; Roshan A. Jain; Seema Chatterjee; Elizabeth R. Gavis Asymmetric mRNA localization is an effective mechanism for establishing cellular and developmental polarity. Posterior localization of oskar in the Drosophila oocyte targets the synthesis of Oskar to the posterior, where...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (1): 95–105.
Published: 01 January 2009
...Ritsuko Suyama; Andreas Jenny; Silvia Curado; Wendy Pellis-van Berkel; Anne Ephrussi During Drosophila oogenesis, oskar mRNA is transported to the posterior pole of the oocyte, where it is locally translated and induces germ-plasm assembly. Oskar protein recruits all of the components necessary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (6): 1107–1117.
Published: 15 March 2008
...Tsubasa Tanaka; Akira Nakamura Cell fate is often determined by the intracellular localization of RNAs and proteins. In Drosophila oocytes, oskar ( osk ) RNA localization and the subsequent Osk synthesis at the posterior pole direct the assembly of the pole plasm, where factors for the germline...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (2): 233–236.
Published: 15 January 2007
... spherical bodies from smaller precursors. Several polar granule components, both protein and RNA, have been identified. One of these, the protein Oskar, acts to initiate granule formation during oogenesis and to recruit other granule components. To investigate whether Oskar has a continuing role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2827–2833.
Published: 01 August 2006
...Andreas Jenny; Olivier Hachet; Péter Závorszky; Anna Cyrklaff; Matthew D. J. Weston; Daniel St Johnston; Miklós Erdélyi; Anne Ephrussi The Drosophila maternal effect gene oskar encodes the posterior determinant responsible for the formation of the posterior pole plasm in the egg, and thus...
Journal Articles
Journal: Development
Development (2006) 133 (8): 1467–1475.
Published: 15 April 2006
..., and found that the gene is essential for viability. During oogenesis, ik2 is required in an NF-κB-independent process that is essential for the localization of oskar and gurken mRNAs; as a result, females that lack ik2 in the germline produce embryos that are both bicaudal and ventralized. The abnormal RNA...
Journal Articles
Journal: Development
Development (2005) 132 (24): 5343–5352.
Published: 15 December 2005
... also occurs in oskar mutants and other segmentation mutants. In hid bicoid double mutants, mis-specified cells in the presumptive head and thorax survive and continue to develop, but they are transformed to adopt a different cell fate. We provide evidence that the terminal torso signaling pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3743–3752.
Published: 15 August 2005
...-10A, while pattern formation determinants such as oskar mRNA are being localized and anchored at specific sites on the cortex. Then fast well-ordered streaming begins during stage 10B, just before nurse cell cytoplasm is dumped into the oocyte. We report that the plus-end-directed microtubule motor...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (3): 459–468.
Published: 01 February 2005
... that vls encodes a divergent WD domain protein and that the three available EMS-induced point mutations cause premature stop codons in the vls ORF. We have generated a null allele that has a stronger phenotype than the EMS mutants. The vls null mutant shows that vls + is required for high levels of Oskar...
Journal Articles
Journal: Development
Development (2004) 131 (6): 1401–1410.
Published: 15 March 2004
... and dorsoventral axes of the Drosophila melanogaster embryo are determined by the activities of localized maternal gene products. At the posterior pole of the oocyte, Oskar directs the assembly of the pole plasm,and is thus responsible for formation of abdomen and germline in the embryo. Tight restriction of oskar...
Journal Articles
Journal: Development
Development (2003) 130 (17): 4201–4215.
Published: 01 September 2003
...Sophie G. Martin; Vincent Leclerc; Katie Smith-Litière; Daniel St Johnston The anteroposterior axis of Drosophila is defined during oogenesis, when the polarisation of the oocyte microtubule cytoskeleton directs the localisation of bicoid and oskar mRNAs to the anterior and posterior poles...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (15): 3705–3714.
Published: 01 August 2002
...Nathalie F. Vanzo; Anne Ephrussi Localization of the maternal determinant Oskar at the posterior pole of Drosophila melanogaster oocyte provides the positional information for pole plasm formation. Spatial control of Oskar expression is achieved through the tight coupling of mRNA localization...
Journal Articles
Journal: Development
Development (2002) 129 (14): 3469–3478.
Published: 15 July 2002
...Rita Sinka; Ferenc Jankovics; Kálmán Somogyi; Tamás Szlanka; Tamás Lukácsovich; Miklós Erdélyi Embryonic germ cell formation and abdomen development in Drosophila requires localisation and site specific translation of oskar mRNA in the posterior part of the oocyte. Targeting of oskar...
Journal Articles
Journal: Development
Development (2002) 129 (2): 517–526.
Published: 15 January 2002
... to the posterior pole in rab11 P2148 oocytes, they are not translated. As Osk is required to anchor oskar mRNA at the posterior pole ( Rongo et al., 1995 ), the lack of oskar translation in rab11 P2148 GLCs could explain the inability of the oskar mRNA ball to resolve into the thin posterior crescent...
Journal Articles
Journal: Development
Development (2001) 128 (14): 2823–2832.
Published: 15 July 2001
...Adam N. Harris; Paul M. Macdonald In Drosophila oocytes, activation of Oskar translation from a transcript localized to the posterior pole is an essential step in the organization of the pole plasm, specialized cytoplasm that contains germline and abdominal body patterning determinants. Oskar...