... combinatorial transcription factor input, feedback and redundancy, are coordinated to drive dve expression in the Drosophila eye. Defective proventriculus Shadow enhancer Dark shadow enhancer Rhodopsin Drosophila retina Photoreceptor Spineless Orthodenticle Spalt Genes are expressed...

...Kay Kotkamp; Martin Klingler; Michael Schoppmeier In the short-germ beetle Tribolium castaneum , the head gap gene orthodenticle ( Tc-otd ) has been proposed to functionally substitute for bicoid , the anterior morphogen unique to higher dipterans. In this study we reanalyzed the function of Tc-otd...

... during regeneration and asexual reproduction (by fission) in the segmented worm Pristina leidyi (Annelida: Oligochaeta). We isolated three genes from Pristina , one homolog of engrailed and two homologs of orthodenticle , and characterized their expression in different developmental contexts. In situ...

...). However, both these hypotheses remain untested. Here, we show that a small regulatory region upstream of the cephalic gap gene orthodenticle (otd) is sufficient to recapitulate early otd expression in the head primordium. This region contains two control elements, each capable of driving otd- like...

...Sandra Leuzinger; Frank Hirth; Daniel Gerlich; Dario Acampora; Antonio Simeone; Walter J. Gehring; Robert Finkelstein; Katsuo Furukubo-Tokunaga; Heinrich Reichert ABSTRACT Members of the orthodenticle gene family are essential for embryonic brain development in animals as diverse as insects...

...Muriel Rhinn; Andrée Dierich; William Shawlot; Richard R. Behringer; Marianne Le Meur; Siew-Lan Ang ABSTRACT The homeobox gene Otx2 is a mouse cognate of the Drosophila orthodenticle gene, which is required for development of the brain, rostral to rhombomere three. We have investigated...

... an excellent model system for determining how the fates of primordia are specified during development. In this study, we investigated how the adjacent primordia of the compound eye and dorsal head vertex are specified. We show that the genes wingless (wg) and orthodenticle (otd) are expressed throughout...

...Ernst A. Wimmer; Stephen M. Cohen; Herbert Jäckle; Claude Desplan ABSTRACT The Drosophila gap-like segmentation genes orthodenticle, empty spiracles and buttonhead ( btd ) are expressed and required in overlapping domains in the head region of the blastoderm stage embryo. Their expression domains...

... hedgehog and wingless specify the identities of specific regions of the head capsule. During eye-antennal disc development, hedgehog and wingless expression initially overlap, but subsequently segregate. This regional segregation is critical to head specification and is regulated by the orthodenticle...

..., which form the head of the adult fruitfly. We demonstrate genetically that there is a graded requirement for the activity of the orthodenticle homeobox gene in forming specific structures of the developing head. Consistent with this result, we show that OTD protein is expressed in a graded fashion...