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Keywords: Organoids
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Journal Articles
Journal: Development
Development (2024) 151 (2): dev202134.
Published: 26 January 2024
...Hahyung Y. Kim; Ishani Sinha; Karen E. Sears; Charlotte Kuperwasser; Gat Rauner ABSTRACT The varying pathways of mammary gland development across species and evolutionary history are underexplored, largely due to a lack of model systems. Recent progress in organoid technology holds the promise...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (22): dev202152.
Published: 16 November 2023
... restriction. However, regulatory mechanisms controlling development of placental epithelial cells, the trophoblasts, remain poorly elucidated. Using trophoblast stem cells (TSCs), trophoblast organoids (TB-ORGs) and primary cytotrophoblasts (CTBs) of early pregnancy, we herein show that autocrine NOTCH3...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (19): dev201871.
Published: 5 October 2023
... cells and neurons. Despite previously characterizing some cell types, many remain undefined. This study aimed to chart the in vitro development timeline of the inner ear organoid to understand the mechanisms at play. Using single-cell RNA sequencing at ten stages during the first 36 days...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (20): dev201696.
Published: 4 September 2023
... (DHFR), a key enzyme in 1C metabolism, is highly expressed in human and mouse neural progenitors at the early stages of neocortical development. Here, we have investigated the role of DHFR in the developing neocortex and report that reducing its activity in human neural organoids and mouse embryonic...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (2): dev200399.
Published: 30 January 2023
... cell-derived organoids has provided insights into the rearrangements that eye progenitors undergo to adopt such a shape. Molecular and pharmacological interference with these rearrangements has further identified the underlying molecular machineries and the physical forces involved...
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201120.
Published: 1 November 2022
...Sabina Kanton; Sergiu P. Paşca ABSTRACT Deconstructing and then reconstructing developmental processes ex vivo is crucial to understanding how organs assemble and how physiology can be disrupted in disease. Human 3D stem cell-derived systems, such as organoids, have facilitated this pursuit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201004.
Published: 31 October 2022
...Anne Grapin-Botton; Yung Hae Kim ABSTRACT Organoids have become one of the fastest progressing and applied models in biological and medical research, and various organoids have now been developed for most of the organs of the body. Here, we review the methods developed to generate pancreas...
Journal Articles
Journal Articles
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (8): dev199904.
Published: 3 May 2022
... clearance. These functions are executed deep within tissues, which are often poorly accessible and subject to environmental variability, especially in humans. Here, we discuss how multicellular 3D systems in a dish – organoids – are transitioning from a proof-of-principle approach to a timely, robust...
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200361.
Published: 22 April 2022
... reprogrammed cells in a degranulation-dependent manner. Importantly, in vivo partial reprogramming is strongly reduced by adoptive transfer of NK cells, whereas it is significantly increased by their depletion. Notably, in the absence of NK cells, the pancreatic organoids derived from OSKM-expressing mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev197947.
Published: 31 March 2022
... organoid systems can now provide unprecedented insights into the physical principles of human development. The lens placode interacts with the presumptive retina to coordinate their invaginations. A rich pool of ECM proteins exists between lens placode and retinal epithelium, and is essential...
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
... and differentiation. Multiple distinct trophoblast states were identified, representing progenitor CTB, column CTB, SCT precursors and EVT. Lineage trajectory analysis identified a progenitor origin that was reproduced in human trophoblast stem cell organoids. Heightened expression of basal cell adhesion molecule...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev192914.
Published: 15 December 2021
... as a common denominator. First, by putting ‘stem’ up front it could shift the focus from the embryo to the stem cells, thereby better positioning it as a model system on its own; complementary to, but not replacing the embryo (in contrast to the popular term ‘embryonic organoid’ or ‘embryoid’). Second...
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199611.
Published: 8 September 2021
...Nicola Gritti; Jia Le Lim; Kerim Anlaş; Mallica Pandya; Germaine Aalderink; Guillermo Martínez-Ara; Vikas Trivedi ABSTRACT Recent years have seen a dramatic increase in the application of organoids to developmental biology, biomedical and translational studies. Organoids are large structures...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199814.
Published: 3 September 2021
... regulators that drive liver cell development and primary liver cancers. We also discuss emerging models derived from pluripotent stem cells, 3D organoids and bioengineering for improved studies of signalling pathways in liver cancer and regenerative medicine. * Author for correspondence ( hoodless...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev194357.
Published: 20 April 2021
... of intestinal crypt cell proliferation. Despite increasing data, in-depth analysis on their specific action on intestinal stem cells is lacking. By using ex vivo 3D organoid cultures and molecular approaches, we observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (20): dev181917.
Published: 15 October 2019
... of factors affecting symmetry breaking and spatial fate choice during this developmental process could prove valuable for in vitro differentiation and organoid formation. * Author for correspondence ( iftachn@tauex.tau.ac.il ) Competing interests The authors declare no competing or financial...
Includes: Supplementary data