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Keywords: Organ of Corti
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev162263.
Published: 22 June 2020
...Elizabeth Carroll Driver; Matthew W. Kelley ABSTRACT The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the primary structure for the perception of sound. Along the length of the cochlear spiral is the organ of Corti, a highly derived and rigorously patterned...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev181339.
Published: 19 September 2019
... the cochlea for sensory development. Cochlea Organ of Corti Otic vesicle Sensory development Gene regulation Shh signaling Mouse The organ of Corti is a specialized sensory structure for hearing in mammals that lines the length of the cochlear duct. It comprises a single row of inner hair...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (16): 2792–2800.
Published: 15 August 2015
...-myc is required for proper morphogenesis of the cochlea and to control correct patterning of the organ of Corti. We show here that the Otx2 gene, a mammalian ortholog of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ear development. Otx2 expression is lost in N...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (16): 3441–3449.
Published: 15 August 2011
... of their directional sensitivity, hair bundles in the cochlea must be uniformly oriented for correct perception of sound. In the auditory sensory epithelium, the organ of Corti (OC), the vertex of the V-shaped hair bundle on every hair cell points toward the lateral edge of the cochlear duct. The uniform hair bundle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (12): 1977–1986.
Published: 15 June 2009
... © 2009. 2009 Hair cell Organ of Corti Inner ear Pillar cell Mouse In mammals sounds are perceived by the organ of Corti (OC), a sensory epithelium that extends along the basal-to-apical axis of the cochlear spiral. The OC comprises highly ordered rows of mechanosensory hair cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (16): 3021–3029.
Published: 15 August 2007
...Bonnie E. Jacques; Mireille E. Montcouquiol; Erynn M. Layman; Mark Lewandoski; Matthew W. Kelley The mammalian auditory sensory epithelium (the organ of Corti) contains a number of unique cell types that are arranged in ordered rows. Two of these cell types, inner and outer pillar cells (PCs...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (11): 2375–2384.
Published: 1 June 2003
.... A., Warchol, M. E. and Corwin, J. T. ( 1993 ). The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture. Development 119 , 1041 -1053. Kelley, M. W. and Bianchi, L. M. ( 2001 ). Development and neural innervation...
Journal Articles
Journal: Development
Development (2002) 129 (14): 3523–3532.
Published: 15 July 2002
...Shengguo Li; Sandy M. Price; Hugh Cahill; David K. Ryugo; Michael M. Shen; Mengqing Xiang The cochlea of the mammalian inner ear contains three rows of outer hair cells and a single row of inner hair cells. These hair cell receptors reside in the organ of Corti and function to transduce mechanical...
Journal Articles
Journal: Development
Development (2002) 129 (10): 2495–2505.
Published: 15 May 2002
...Ping Chen; Jane E. Johnson; Huda Y. Zoghbi; Neil Segil During embryonic development of the inner ear, the sensory primordium that gives rise to the organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of inner and outer sensory hair cells separated from each...
Journal Articles
Journal: Development
Development (2000) 127 (15): 3373–3383.
Published: 1 August 2000
... differentiation * Author for correspondence (e-mail: Francois.DeRibaupierre@IPHYSIOL.unil.ch ) 29 04 1999 10 07 1999 © 2000 by Company of Biologists 2000 Notch1 Jagged1 Jagged2 Organ of Corti Inner ear Rat The mammalian cochlea is an excellent model system to study...
Journal Articles
Journal: Development
Development (1999) 126 (8): 1581–1590.
Published: 15 April 1999
...Ping Chen; Neil Segil Strict control of cellular proliferation is required to shape the complex structures of the developing embryo. The organ of Corti, the auditory neuroepithelium of the inner ear in mammals, consists of two types of terminally differentiated mechanosensory hair cells...