...Elizabeth Carroll Driver; Matthew W. Kelley ABSTRACT The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the primary structure for the perception of sound. Along the length of the cochlear spiral is the organ of Corti, a highly derived and rigorously patterned...

... approach identifies Shh-responsive genes and associated regulatory sequences with known and previously uncharacterized roles in cochlear morphogenesis, including genes that prime the cochlea for sensory development. Cochlea Organ of Corti Otic vesicle Sensory development Gene regulation Shh...

... in the mouse cochlea depends on integration of developmental signals at highly conserved regions of the Atoh1 promoter. Cochlear development Organ of Corti Hair cell regeneration Transdifferentiation Atoh1 Hes5 Mouse The auditory sensory epithelium in mammals, the organ of Corti...

...-myc is required for proper morphogenesis of the cochlea and to control correct patterning of the organ of Corti. We show here that the Otx2 gene, a mammalian ortholog of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ear development. Otx2 expression is lost in N...

... structure in the organ of Corti. Taken together, results reported here suggest that from late embryonic (left) to early postnatal (right) development, outer hair cells (OHCs) have an increasing reliance on the actin network (red) and a decreasing reliance on microtubules (blue). By contrast, supporting...

... to be the critical polarizing event that orchestrates hair bundle morphogenesis and orientation. Because of their directional sensitivity, hair bundles in the cochlea must be uniformly oriented for correct perception of sound. In the auditory sensory epithelium, the organ of Corti (OC), the vertex of the V...

[email protected] ) 6 4 2009 © 2009. 2009 Hair cell Organ of Corti Inner ear Pillar cell Mouse Myosin II has also been shown to regulate CE during germband extension in Drosophila through modulation of junctional remodeling( Bertet et al., 2004 ; Zallen and Wieschaus, 2004...

...Bonnie E. Jacques; Mireille E. Montcouquiol; Erynn M. Layman; Mark Lewandoski; Matthew W. Kelley The mammalian auditory sensory epithelium (the organ of Corti) contains a number of unique cell types that are arranged in ordered rows. Two of these cell types, inner and outer pillar cells (PCs...

... exit, are achieved. Here, we show that during inner ear development transcriptional regulation of p27 Kip1 is the primary determinant of a wave of cell cycle exit that dictates the number of postmitotic progenitors destined to give rise to the hair cells and supporting cells of the organ of Corti...

... with an initial, non-random orientation that is biased towards the final orientation of each cell. Following initial development, individual stereociliary bundles gradually reorient to obtain their final orientation. Our observations suggest that hair cells within the mammalian organ of Corti develop in a similar...

...Shengguo Li; Sandy M. Price; Hugh Cahill; David K. Ryugo; Michael M. Shen; Mengqing Xiang The cochlea of the mammalian inner ear contains three rows of outer hair cells and a single row of inner hair cells. These hair cell receptors reside in the organ of Corti and function to transduce mechanical...

...Ping Chen; Jane E. Johnson; Huda Y. Zoghbi; Neil Segil During embryonic development of the inner ear, the sensory primordium that gives rise to the organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of inner and outer sensory hair cells separated from each...

... differentiation * Author for correspondence (e-mail: [email protected] ) 29 04 1999 10 07 1999 © 2000 by Company of Biologists 2000 Notch1 Jagged1 Jagged2 Organ of Corti Inner ear Rat The mammalian cochlea is an excellent model system to study...

...Ping Chen; Neil Segil Strict control of cellular proliferation is required to shape the complex structures of the developing embryo. The organ of Corti, the auditory neuroepithelium of the inner ear in mammals, consists of two types of terminally differentiated mechanosensory hair cells...