...-mediated repression. Moreover, we show that accumulation of Oskar activity requires the Drosophila homolog of Cytoplasmic Polyadenylation Element Binding protein (CPEB), Orb. As posterior localization of oskar mRNA is an essential prerequisite for its translation, it was critical to identify an allele...

...Jacqueline S. Chang; Lihua Tan; Melisande R. Wolf; Paul Schedl The orb gene encodes an RNA recognition motif (RRM)-type RNA-binding protein that is a member of the cytoplasmic polyadenylation element binding protein (CPEB) family of translational regulators. Early in oogenesis, orb is required...

...Lihua Tan; Jacqueline S. Chang; Alexandre Costa; Paul Schedl ABSTRACT The RRM-type RNA binding protein Orb plays a central role in the establishment of polarity in the Drosophila egg and embryo. In addition to its role in the formation and initial differentiation of the egg chamber, orb is required...

...Valerie Lantz; Linda Ambrosio; Paul Schedl We report the identification of a new gene, orb , which appears to be expressed only in the gennline and encodes ovarian-and testis-specific transcripts. The predicted proteins contain two regions with similarity to the RRM family of RNA-binding proteins...