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Keywords: Optogenetics
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Journal Articles
Journal: Development
Development (2021) 148 (18): dev199767.
Published: 2 August 2021
... and context, and therefore it would be necessary to more directly validate the causal relationship through an approach such as optogenetics ( Aoki et al., 2013 ; Toettcher et al., 2013 ; Johnson and Toettcher, 2019 ). We first introduce investigations of temporal dynamics of ERK activation at the single...
Journal Articles
Journal: Development
Development (2020) 147 (23): dev194316.
Published: 4 December 2020
... generation at apical cell sides, but several studies indicate a role of mechanical tension at lateral cell sides in this process. However, whether lateral tension increase is sufficient to drive epithelial folding remains unclear. Here, we have used optogenetics to locally increase mechanical force...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev183640.
Published: 17 June 2020
...- regulatory elements and the conditionality of optogenetics. Our studies also demonstrate differences between the nitroreductase and M2 systems that influence their efficacies for specific applications. Using this integrative approach, we have ablated cells in zebrafish embryos with both spatial and temporal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev175067.
Published: 22 October 2019
... in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo , providing a powerful new tool to perturb developmental processes at a wide range of spatiotemporal scales. In this Primer, we describe the most commonly used optogenetic tools, their application...
Journal Articles
Journal: Development
Development (2017) 144 (2): 345–355.
Published: 15 January 2017
...Anna Reade; Laura B. Motta-Mena; Kevin H. Gardner; Didier Y. Stainier; Orion D. Weiner; Stephanie Woo ABSTRACT Here, we describe an optogenetic gene expression system optimized for use in zebrafish. This system overcomes the limitations of current inducible expression systems by enabling robust...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4085–4094.
Published: 1 November 2016
... and differentiation. The lack of tools to manipulate signaling pathways dynamically in space and time has been a major technical challenge for biologists. Optogenetic techniques, which utilize light to control protein functions in a reversible fashion, hold promise for modulating intracellular signaling networks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3627–3636.
Published: 1 October 2014
... than 24 h. Accumulating evidence, together with recently developed optogenetic approaches, suggests that such ultradian oscillators play important roles during cell fate decisions, and analyzing the functional links between ultradian oscillation and cell fate determination will contribute to a deeper...