... and mTOR signaling downstream of nutrients. Neurogenesis Cell cycle Nutrition Stasis G2 arrest Optic tectum Access to nutrients is essential for normal development. Animals must be able to cope with variations in nutrient availability in order to survive and produce viable offspring...

...Yuji Watanabe; Chie Sakuma; Hiroyuki Yaginuma The optic tectum comprises multiple layers, which are formed by radial and tangential migration during development. Here, we report that Neuropilin 1 (NRP1)-mediated Sema3A signals are involved in the process of tectal laminar formation, which...

...Minoru Omi; Hidekiyo Harada; Yuji Watanabe; Jun-ichi Funahashi; Harukazu Nakamura The chick optic tectum consists of 16 laminae. Here, we report contribution of En2 to laminar formation in chick optic tecta. En2 is specifically expressed in laminae g-j of stratum griseum et fibrosum superficiale...

... progenitors (SAPs) are accessible for long-term in vivo imaging. They form a neuroepithelial layer adjacent to the optic tectum, which has transitory fast-amplifying progenitors (FAPs) at its margin. The presence of these SAPs and FAPs in separate domains provided the opportunity to data mine the ZFIN...

...)axis of the optic tectum. EphB receptors are expressed in a low to high DV gradient by retinal ganglion cells (RGCs), and ephrin-B1 is expressed in a low to high LM gradient in the tectum. RGC axons lack DV ordering along the LM tectal axis, but directionally extend interstitial branches that establish...

... hybridization studies have been conducted, in conjunction with pulse-labeling of S-phase nuclei, to compare NeuroM to NeuroD expression in the developing nervous system. In spinal cord and optic tectum, NeuroM expression precedes that of NeuroD . It is transient and restricted to cells lining the ventricular...

... following tectal ablation or transplantation to the coelomic cavity. Thus, RGC subsets acquire distinct neurotransmitter phenotypes in the absence of extraretinal cues. In the mature optic tectum, SPand AChR-positive RGC axonal arbors are confined to distinct retinorecipient (synaptic) laminae...

... of axonal processes during both pathfinding and activity-dependent remodeling ( Landmesser et al., 1990 ; Tang et al., 1992 , 1994 ). polysialic acid optic axons visual system development axon fasciculation axon guidance mechanism optic tectum optic tract chick © 1995 by Company...

... in the optic tectum already 2 days before the arrival of the first retinal ganglion cell axons, suggesting an early role of BDNF in tectal development. After the beginning of tectal innervation, BDNF mRNA levels markedly increased, and optic stalk transection at day 4 (which prevents subsequent tectal...

... cell types, we used a recombinant retrovirus to label precursor cells in the chick optic tectum with a heritable marker, the E. coli lacZ gene. The progeny of the infected cells were detected at later stages of development with a histochemical stain for the lacZ gene product. Radial glia were...

... by Company of Biologists 1991 chick embryo development engrailed neural tube transplantation quail optic tectum cerebellum Nakamura has shown that the prosencephalic alar plate, when transplanted into the mesencephalic vesicle (similar to our PM surgeries), has the capacity...

... analyzed the distribution of the protein in the head tissue and in the dissected brain of tailbud stage embryos. In addition to the main band of expression at the midbrain–hindbrain boundary, we show that the protein is expressed in three novel areas: the mandibular arch, the optic tectum and the region...

... of Anatomy and Cell Biology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, UK (to whom correspondence should be addressed) 02 08 1989 © 1989 by Company of Biologists 1989 laminin laminin receptors neuron retinal ganglion cell optic tectum neurite chick embryo...

... of growth of the optic tectum. The formation of patterns of spots or spots mixed together with stripes following nerve transection after the end of the main phase of tectal histogenesis, and when 50 % of the optic fibres had already reached the tectum, is attributed to an unequal competition between the two...

... is not described by Straznicky & Hiscock and our histogenetic studies between 2 and 12 months after metamorphosis show no such asymmetry. retina optic tectum histogenesis amphibia ocular migration Xenopus laevis autoradiography The amphibian retinotectal projection was established...

... the chiasma . J. Embryol. exp. Morph . 83 , 1 – 14 . Fawcett , J. W. & Willshaw , D. J. ( 1982 ). Compound eyes project stripes on the optic tectum in Xenopus . Nature 296 , 350 – 352 . 10.1038/296350a0 Feldman , J. D. , Gaze , R. M. & Keating , M. J...