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Keywords: Oocyte
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (23): dev202151.
Published: 13 December 2023
... subfertility, impairs oocyte maturation and partially arrests early embryonic development. Using dual-omic sequencing, we observed that Eif4enif1 haploinsufficiency significantly altered both transcriptome and translatome in mouse oocytes, by which we further revealed oocyte mitochondrial hyperfusion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (20): dev202148.
Published: 25 October 2023
... embryogenesis. In this Review, we summarize recent studies on oocyte and embryo metabolism and its regulation, with a particular focus on its association with key developmental events such as fertilization, zygote genome activation and cell fate determination. In addition, we discuss the mechanisms of certain...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (13): dev201728.
Published: 7 July 2023
...Maëlys Loh; Fred Bernard; Antoine Guichet ABSTRACT Microtubules and their associated motors are important players in nucleus positioning. Although nuclear migration in Drosophila oocytes is controlled by microtubules, a precise role for microtubule-associated molecular motors in nuclear migration...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (12): dev201572.
Published: 13 June 2023
...Zhihua Zhang; Ruyi Liu; Hongbin Zhou; Qun Li; Ronggui Qu; Weijie Wang; Zhou Zhou; Ran Yu; Yang Zeng; Jian Mu; Biaobang Chen; Xuejiang Guo; Qing Sang; Lei Wang ABSTRACT The accumulation and storage of maternal mRNA is crucial for oocyte maturation and embryonic development. PATL2 is an oocyte...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (2): dev201037.
Published: 30 January 2023
... that the original work is properly attributed. Summary: A survey of germ granules across organisms and developmental stages, highlighting emerging themes regarding granule regulation, dynamics and proposed functions. RNA Condensate Germ granule Oocyte Primordial germ cell Sperm National...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (21): dev199560.
Published: 29 October 2021
...Mansour Aboelenain; Karen Schindler ABSTRACT Mammalian oocytes are transcriptionally quiescent, and meiosis and early embryonic divisions rely on translation of stored maternal mRNAs. Activation of these mRNAs is mediated by polyadenylation. Cytoplasmic polyadenylation binding element 1 (CPEB1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196931.
Published: 18 January 2021
... regulatory protein 1 (ESRP1) and found that it induced female infertility in mice. Esrp1 deletion perturbed spindle organization, chromosome alignment and metaphase-to-anaphase transformation in oocytes. The first polar body extrusion was blocked during oocyte meiosis owing to abnormal activation of spindle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev189985.
Published: 14 August 2020
...Naokazu Inoue; Takako Saito; Ikuo Wada ABSTRACT Gamete fusion is an indispensable process for bearing offspring. In mammals, sperm IZUMO1–oocyte JUNO recognition essentially carries out the primary step of this process. In oocytes, CD9 is also known to play a crucial role in gamete fusion...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183764.
Published: 17 March 2020
... trimethylation and meiotic cell cycle progression in mouse oocytes . Nat. Commun.   9 , 3477 . 10.1038/s41467-018-05930-x Sherman , S. L. , Petersen , M. B. , Freeman , S. B. , Hersey , J. , Pettay , D. , Taft , L. , Frantzen , M. , Mikkelsen , M. and Hassold , T. J...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (23): dev182519.
Published: 2 December 2019
... owing to the untimely destruction of cohesin. Recently, we have proved that cyclin B2 can compensate for cyclin B1 in CDK1 activation for the oocyte meiosis G2/M transition. In the present study, we identify an interaction between cyclin B2/CDK1 and separase in mouse oocytes. We find that cyclin B2...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (22): dev181925.
Published: 25 November 2019
..., play key roles in the regulation of cellular lipid metabolism. Although it is well known that mammalian oocytes and embryos contain LDs and that the amount of LDs varies among animal species, their physiological functions remain unclear. In this study, we have developed a method based on two-step...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (4): dev161893.
Published: 23 February 2018
...-1-1/ Summary: A forced lipophagy system, established by expressing an autophagy adaptor on the surface of lipid droplets, demonstrates that depletion of lipid droplets in fertilized mouse embryos causes developmental retardation. Autophagy Lipid droplet Oocyte Embryo Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3789–3797.
Published: 15 October 2017
..., is a highly conserved and ubiquitously expressed protein. However, its roles in meiotic oocytes are not known. In the present study, we find that mouse oocytes depleted of HDAC3 are unable to completely progress through meiosis, and are blocked at metaphase I. These HDAC3 knockdown oocytes show spindle...
Includes: Supplementary data
Journal Articles
Journal Articles