... the number of Olig2 + motoneuron progenitors and Hb9 + motoneurons without a significant effect on cell survival or proliferation. These effects were a specific and direct consequence of Shh reduction in the mesoderm. In addition, grafting notochords in a basal but not apical location, vis-à-vis the tube...

... neurons are derived from olig2 -expressing progenitors and regeneration is promoted by dopamine (this study and Reimer et al., 2008 ; Reimer et al., 2013 ). We show here that motor neuron regeneration and functional recovery in larvae are very rapid, occurring within 48 h, whereas in adults, motor...

... of Gsx2 -derived OPCs within the adjacent mantle regions of the cortex before birth at E18.5. Moreover, using Olig2 cre to conditionally inactivate Gsx2 throughout the ventral telencephalon with the exception of the dorsal (d)LGE, we found that the increase in cortical OPCs in Gsx2 germline mutants...

.... The mechanisms that regulate their oligodendrocyte or astrocyte fate and the degree to which they exhibit lineage plasticity in vivo have remained unclear. The basic helix-loop-helix transcription factor Olig2 is required for oligodendrocyte specification and differentiation. We have found that Olig2 expression...

... with Shh, FGF-receptor signalling controls the expression of olig2 , a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes. Second, FGF-receptor signalling controls the development of both oligodendrocyte progenitors and astroglia through the regulation of sox9...

...Jeff Cai; Ying Chen; Wen-Hui Cai; Edward C. Hurlock; Heng Wu; Steven G. Kernie; Luis F. Parada; Q. Richard Lu The mechanisms underlying astrocyte heterogeneity in the developing mouse brain are poorly understood. The bHLH transcription factor Olig2 is essential for motoneuron and oligodendrocyte...

..., precursors with high levels of Notch activity remain as precursors, whereas those that have less activity undergo a final division and give rise to neurons. Subsequently, differential Notch activity specifies some olig2 + sibling neurons for different fates. In particular, cells with relatively high Notch...

..., Zfp488 can interact and cooperate with the bHLH transcription factor Olig2 to promote precocious and ectopic oligodendrocyte differentiation. Furthermore, knockdown of Zfp488 via RNAi in an oligodendroglial cell line leads to the downregulation of myelin gene expression. Taken together, these data...

... that is associated with induction of the obligate oligogenic gene Olig2 . Cyclopamine, a potent inhibitor of hedgehog signalling, did not block the formation of oligodendrocytes from FGF2-treated neurosphere cultures. Furthermore,neurospheres generated from SHH null mice also produced oligodendrocytes, even...

... generation in the spinal cord. We report that Nkx6.1 also controls oligodendrocyte development in the developing spinal cord, possibly by regulating Olig gene expression in the ventral neuroepithelium. In Nkx6.1 mutant spinal cords, expression of Olig2 in the motoneuron progenitor domain is diminished...

...Hui Fu; Yingchuan Qi; Min Tan; Jun Cai; Hirohide Takebayashi; Masato Nakafuku; William Richardson; Mengsheng Qiu In this study, we have investigated the relationship of Olig2 + and Nkx2.2+ oligodendrocyte progenitors (OLPs) by comparing the expression of Olig2 and Nkx2.2 in embryonic chicken...

...Susana Nery; Hynek Wichterle; Gord Fishell This study addresses the role of Sonic hedgehog (Shh) in promoting the generation of oligodendrocytes in the mouse telencephalon. We show that in the forebrain, expression of the early oligodendrocyte markers Olig2, plp/dm20 and PDGFRα corresponds...