...Jonathan D. Louie; Benjamin H. Bromberg; Matthew J. Zunitch; James E. Schwob ABSTRACT Horizontal basal cells (HBCs) residing within severely damaged olfactory epithelium (OE) mediate OE regeneration by differentiating into odorant-detecting olfactory sensory neurons (OSNs) and other tissue...

... development. Neurogenesis in the vertebrate olfactory epithelium persists from embryonic stages through adulthood. The role Sox2 plays for the development of the olfactory epithelium and neurogenesis within has, however, not been determined. Here, by analysing Sox2 conditional knockout mouse embryos and chick...

... mechanisms engaged in these interactions remain poorly understood. In the developing olfactory epithelium (OE), neural stem/progenitor cells give rise to odorant-detecting olfactory receptor neurons (ORNs) and glial-like sustentacular (SUS) cells. Here, we show in mice that the transmembrane receptor...

...Kimberly K. Gokoffski; Hsiao-Huei Wu; Crestina L. Beites; Joon Kim; Euiseok J. Kim; Martin M. Matzuk; Jane E. Johnson; Arthur D. Lander; Anne L. Calof Studies of the olfactory epithelium model system have demonstrated that production of neurons is regulated by negative feedback. Previously, we...

...Shimako Kawauchi; Joon Kim; Rosaysela Santos; Hsiao-Huei Wu; Arthur D. Lander; Anne L. Calof Foxg1, a winged-helix transcription factor, promotes the development of anterior neural structures; in mice lacking Foxg1 , development of the cerebral hemispheres and olfactory epithelium (OE) is severely...

...Shimako Kawauchi; Jianyong Shou; Rosaysela Santos; Jean M. Hébert; Susan K. McConnell; Ivor Mason; Anne L. Calof In vertebrate olfactory epithelium (OE), neurogenesis proceeds continuously, suggesting that endogenous signals support survival and proliferation of stem and progenitor cells. We used...

... the placode territory becomes confined to the head, and how neural crest and placode fates diversify. * Author for correspondence (e-mail: [email protected] ) 6 7 2005 ©2005. 2005 Chick Quail Placode Lens Inner ear Olfactory epithelium Cranial ganglia The sensory...

...Nicole Wagner; Kay-Dietrich Wagner; Annette Hammes; Karin M. Kirschner; Valerie P. Vidal; Andreas Schedl; Holger Scholz Neuronal lineage formation in the developing olfactory epithelium has been extensively studied at the cellular level, but little is known about the genes that control...

...Elise Cau; Simona Casarosa; François Guillemot bHLH transcription factors are expressed sequentially during the development of neural lineages, suggesting that they operate in genetic cascades. In the olfactory epithelium, the proneural genes Mash1 and neurogenin1 are expressed at distinct steps...

...Jianyong Shou; Richard C. Murray; Peter C. Rim; Anne L. Calof ABSTRACT In olfactory epithelium (OE) cultures, bone morphogenetic proteins (BMPs) can strongly inhibit neurogenesis. Here we provide evidence that BMPs also promote, and indeed are required, for OE neurogenesis. Addition of the BMP...

... the isolation of a novel murine gene, Math4C/neurogenin1 , which is distantly related to the Drosophila proneural gene atonal . We show that Math4C/neurogenin1 and the basic helix-loop-helix gene Mash1 are expressed in the olfactory epithelium by different dividing progenitor populations, while another basic...

... of Siah-2 by hybridisation histo-chemistry shows that it is expressed at a higher level in a restricted number of sites during development, including the olfactory epithelium, retina, forebrain and pro-liferating cartilage of developing bone. The striking degree of sequence homology observed between...

... passages, whereas keratan sulphate is absent beneath the respiratory epithelium. 04 04 1989 © 1989 by Company of Biologists 1989 chick embryo nasal placode olfactory epithelium collagen type II keratan sulphate heparan sulphate proteoglycan N-CAM lectins ConA DBA PNA RCA1...