...) or all mature VSNs. Smad4 loss of function in immature bVSNs compromises dendritic knob formation, pheromone induced activation, correct glomeruli formation in the accessory olfactory bulb (AOB) and survival. However, Smad4 loss of function in all mature VSNs only compromises correct glomeruli formation...

...Åsa Kolterud; Mattias Alenius; Leif Carlsson; Staffan Bohm Progenitor cells in the mouse olfactory epithelium generate over a thousand subpopulations of neurons, each expressing a unique odorant receptor (OR)gene. This event is under the control of spatial cues, since neurons in different...

...Song S. Wang; Joseph W. Lewcock; Paul Feinstein; Peter Mombaerts; Randall R. Reed The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH)transcription factors has been implicated in olfactory system gene regulation,nervous system development and B-cell differentiation. Ebf ( O/E1...

...Bernd Knöll; Hannes Schmidt; William Andrews; Sarah Guthrie; Adrian Pini; Vasi Sundaresan; Uwe Drescher The vomeronasal projection conveys information provided by pheromones and detected by neurones in the vomeronasal organ (VNO) to the accessory olfactory bulb (AOB) and thence to other regions...

...Lay-Hong Ang; Jenny Kim; Vitaly Stepensky; Huey Hing The convergence of olfactory axons expressing particular odorant receptor(Or) genes on spatially invariant glomeruli in the brain is one of the most dramatic examples of precise axon targeting in developmental neurobiology. The cellular...

...Mattias Alenius; Staffan Bohm Olfactory sensory neurons (OSNs) are individually specified to express one odorant receptor (OR) gene among ∼1000 different and project with precision to topographically defined convergence sites, the glomeruli, in the olfactory bulb. Although ORs partially determine...

... RA administration allows development to proceed and results in the establishment of additional sites of RA synthesis linked to Raldh1 expression in the dorsal retina and to Raldh3 expression in the ventral retina, olfactory pit and urinary tract. Unexpectedly, conditionally rescued Raldh2 –/– embryos...