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Keywords: Off-target
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Journal Articles
Alexander Hruscha, Peter Krawitz, Alexandra Rechenberg, Verena Heinrich, Jochen Hecht, Christian Haass, Bettina Schmid
Journal:
Development
Development (2013) 140 (24): 4982–4987.
Published: 15 December 2013
... system has recently been applied in cell lines and vertebrates. However, we still have very limited information about the efficiency of mutagenesis, germline transmission rates and off-target effects in genomes of model organisms. We now demonstrate that CRISPR/Cas9 mutagenesis in zebrafish is highly...
Includes: Supplementary data
