...Wei-Hao Huang; Kreeti Kajal; Ryan Himawan Wibowo; Oyundari Amartuvshin; Shih-Han Kao; Elham Rastegari; Chi-Hung Lin; Kuan-Lin Chiou; Hai-Wei Pi; Chau-Ti Ting; Hwei-Jan Hsu ABSTRACT High-sugar diets (HSDs) often lead to obesity and type 2 diabetes, both metabolic syndromes associated with stem cell...

...Rodrigo Dutra Nunes; Daniela Drummond-Barbosa ABSTRACT Obesity is linked to reduced fertility in various species, from Drosophila to humans. Considering that obesity is often induced by changes in diet or eating behavior, it remains unclear whether obesity, diet, or both reduce fertility. Here, we...

... and the postnatal development of obesity has been established. Here, by comparing adipocytes differentiated from mesenchymal stem cells (MSCs) taken from the umbilical cord and derived from normal and growth-restricted neonates, we identified the transcription factor SOX6 as highly expressed only in growth...

..., the temporal and mechanistic origins of these changes, and whether they are reversible, are unknown. We now show that, in obese female mice, cumulus-oocyte complexes exhibit endoplasmic reticulum (ER) stress, high levels of intracellular lipid, spindle abnormalities and reduced PTX3 extracellular matrix...

... and adulthood. We speculate that this mechanism could be important in explaining the well-established link between obesity and insulin resistance that is observed in Type 2 diabetes. * Author for correspondence (e-mail: [email protected] ) 25 9 2006 © 2006. 2006 Drosophila...

... an increase in weight gain and body length, a susceptibi lity to hepatic, pulmonary and mammary tumors, and a suppression of the agouti phenotype, which results in a yellow coat color. To investigate the cellular action of A y with regard to its effects upon embryonic viability and adult-onset obesity, we...