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Psi depletion reduces proliferation.  (A) Third instar larval wing discs wi...
Published: 24 January 2023
Fig. 1. Psi depletion reduces proliferation. (A) Third instar larval wing discs with ser -GAL4 expression of UAS - FUCCI with two alternate Psi RNAi lines, or control, stained using anti-pH3 antibody. (B) Quantification of the proportion of cells undergoing each cell cycle stage ( n >10)... More
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Psi binds multiple genomic regions, including  Myc .  (A) Psi- and RNA Pol ...
Published: 24 January 2023
Fig. 2. Psi binds multiple genomic regions, including Myc . (A) Psi- and RNA Pol II-binding profiles across the Myc gene in larval wing discs ( sd -GAL4 driver used for targeted Psi-DamID and RNA Pol-DamID), shown as log 2 of the ratio to Dam-only control. (B) Average Pol and Psi binding acr... More
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Significantly altered genes after  Psi  knockdown in wing discs.  (A) Genes...
Published: 24 January 2023
Fig. 3. Significantly altered genes after Psi knockdown in wing discs. (A) Genes with statistically significant altered expression after Psi knockdown at FDR<0.01. Top 50 genes with greatest fold change and smallest P -value are labelled. Myc and stg are highlighted with black square... More
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Psi binds and regulates developmental genes.  (A) Intersection of different...
Published: 24 January 2023
Fig. 4. Psi binds and regulates developmental genes. (A) Intersection of differentially expressed genes after Psi knockdown with genes bound by Psi. (B) MA plot showing only genes bound by Psi (blue) while statistically significant DGE events at FDR<0.01 are shown in red. (C) Fold change an... More
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Stg overexpression rescues impaired growth associated with Psi depletion.  ...
Published: 24 January 2023
Fig. 5. Stg overexpression rescues impaired growth associated with Psi depletion. (A) Psi and RNA Pol II binding profiles across the stg gene in larval wing discs (log 2 of the ratio to Dam-only control). (B) Adult wings with ser -GAL4 driven knockdown of Psi alone or in combination with ... More
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Repression of  tok  is required for Psi-dependent cell division.  (A) Larva...
Published: 24 January 2023
Fig. 6. Repression of tok is required for Psi-dependent cell division. (A) Larval wing discs with ser -GAL4-driven tok overexpression (OE) and/or Psi RNAi, or tok 1 / tok 3 transheterozygotes with or without ser -GAL4 driven Psi RNAi KD stained using anti-pH3 to detect mitosis. (B)... More
Journal Articles
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Inception increases the base editing scope through  de novo  PAM generation...
Published: 23 January 2023
Fig. 1. Inception increases the base editing scope through de novo PAM generation. (A) Schematic representation of the one-shot inception approach (simultaneous application of two base editors and two guide RNAs). If the adenosine(s) of NGA, NAA and NAG motifs are contained within the canonica... More
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Inception efficiently introduces loss-of-pigmentation mutations in  oca2 . ...
Published: 23 January 2023
Fig. 2. Inception efficiently introduces loss-of-pigmentation mutations in oca2 . (A) Loss-of-function mutations via inception at the oca2 locus by synonymous de novo PAM generation in step 1 (ABE8e, CAG>CGG=p.A337A) and subsequent non-synonymous editing (ancBE4max, CAG>TAG=p.Q333* an... More
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Inception efficiently introduces locally confined multi-codon changes in  k...
Published: 23 January 2023
Fig. 3. Inception efficiently introduces locally confined multi-codon changes in kcnh6a . (A) Local multi-codon editing via inception (both non-synonymous; anticipated edits are indicated by black arrows) at the kcnh6a locus to create hypomorphic alleles with ABE8e and two guide RNAs [ kcnh6a... More
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Efficient splice site acceptor removal via inception in  rx3 .  (A) A splic...
Published: 23 January 2023
Fig. 4. Efficient splice site acceptor removal via inception in rx3 . (A) A splice acceptor site mutation (CAG>CAA, black outlined box) in rx3 via intronic de novo PAM generation ( rx3-step1 guide RNA, ABE8e; GAG>GGG) and subsequent C-to-T splice acceptor site editing [sequence adjus... More
Journal Articles
Journal: Development
Development (2023) 150 (2): e150_e0203.
Published: 20 January 2023
Journal Articles
Journal Articles
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Post-embryonic depletion of CYK-4 results in sterility and a spermathecal m...
Published: 20 January 2023
Fig. 1. Post-embryonic depletion of CYK-4 results in sterility and a spermathecal morphogenesis phenotype. (A) Confocal images of control (EV RNAi) and cyk-4(RNAi) adults. The control image shows oocytes (oo), the spermatheca (sp), and a nicely formed uterus (ut) filled with multiple embryos (... More
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cyk-4  RNAi worms show cell division defects in the spermathecal lineage.  ...
Published: 20 January 2023
Fig. 2. cyk-4 RNAi worms show cell division defects in the spermathecal lineage. (A) Maximum intensity projections of the spermatheca in control and cyk-4(RNAi) hermaphrodites carrying the nuclear marker P F55B11.3 ::GFP::H2B. Arrows indicate clustered nuclei. (B) Graph showing the average n... More