...Jaroslav Ferenc; Aissam Ikmi ABSTRACT Nutritional and metabolic cues are integral to animal development. Organisms use them both as sustenance and environmental indicators, fueling, informing and influencing developmental decisions. Classical examples, such as the Warburg effect, clearly illustrate...

... and disease’ on 24-25th March 2021. Metabolism Cell fate Metabolic plasticity Nutrition Development Metabolism and biochemistry have long been studied in vitro or in homogenized cells and tissues. This has led to an in-depth knowledge of core metabolic pathways. However, we are only now...

... as metabolic homeostasis and cancer. The control of organ and body growth by nutrition involves sensor and effector pathways. Since the discovery of the Target of Rapamycin (TOR) network in yeast and its conservation in metazoans, we have gained a better knowledge of the cellular machinery that couples...

... ; Reiter et al., 2012 ). On the other hand, the majority of programmed cell death occurs as a result of the DNA-damage checkpoint at the G2/M transition, so lengthening G2 may allow for DNA repair in cells that were nutritionally stressed during S-phase replication ( Shaltiel et al., 2015 ). Nonetheless...

... be nutritionally regulated via TOR signalling in the PG, which, similar to IIS, promotes expression of the enzymes required for synthesis of ecdysone starting from cholesterol. A recent study has shown that this is controlled in part by a TOR-mediated cell cycle checkpoint, with TOR being required...

... M. ( 2005 ). Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release . Curr. Biol. 15 , 1785 – 1795 . Chell J. M. , Brand A. H. ( 2010 ). Nutrition-responsive glia control exit of neural stem cells from quiescence...

...Billel Benmimoun; Cédric Polesello; Lucas Waltzer; Marc Haenlin The interconnected Insulin/IGF signaling (IlS) and Target of Rapamycin (TOR) signaling pathways constitute the main branches of the nutrient-sensing system that couples growth to nutritional conditions in Drosophila . Here, we...

... similarities to the mammalian liver and white adipose tissue (Britton et al., 1998). Eukaryotes possess a second and more ancient nutrition-regulated system,involving the kinase TOR (target of rapamycin)( Jacinto and Hall, 2003 ),which is responsive to local nutrient levels, particularly amino acids...

... in nutritionally deprived larvae could be bypassed by expressing G1/S regulators, we ectopically expressed either DmcycE or dE2F and its binding partner dDP in starved larvae using a heat-shock inducible promoter. We also expressed dE2F and dDP using the flp-out Gal4 method (see Materials and Methods...