.... Here, we demonstrate a feed-forward mechanism of mDA neuron development involving Nurr1 and Foxa2. Nurr1 acts as a transcription factor for DA phenotype gene expression. However, Nurr1-mediated DA gene expression was inactivated by forming a protein complex with CoREST, and then recruiting histone...

...Chang-Hwan Park; Mi-Sun Lim; Yong-Hee Rhee; Sang-Hoon Yi; Boe-Kyoung Kim; Jae-Won Shim; Yong Ho Kim; Sung Jun Jung; Sang-Hun Lee Neural stem/progenitor cell (NSC/NPC) cultures can be a source of dopamine (DA) neurons for experimental and transplantation purposes. Nurr1, a steroid receptor...

... ( Mash1 in the Ngn2 locus). Our results demonstrate that Ngn2 is required for the differentiation of Sox2 + ventricular zone progenitors into Nurr1 + postmitotic dopaminergic neuron precursors in the intermediate zone, and that it is also likely to be required for their subsequent differentiation...

..., and the region-specific transcription factors Ptx3 and Nurr1. Here we use undifferentiated progenitors to probe the events leading to the dopaminergic phenotype and find that the influences of Nurr1 can be temporally and mechanistically uncoupled from the patterning influences of sonic hedgehog and FGF-8...