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Keywords: Numb
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Journal Articles
Journal: Development
Development (2020) 147 (3): dev184390.
Published: 7 February 2020
... melanogaster Suppressor of Deltex Gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase . Genetics   152 , 567 - 576 . Couturier , L. , Mazouni , K. and Schweisguth , F. ( 2013 ). Numb localizes at endosomes and controls the endosomal sorting of Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1607–1618.
Published: 1 May 2017
... cells and to both supporting and interstitial cell lineages, implying that cells in the CE domain are multipotent progenitors, and suggesting that an asymmetric division is involved in the acquisition of gonadal cell fates. We found that NUMB is asymmetrically localized in CE cells, suggesting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2185–2196.
Published: 1 June 2011
...Yingshi Ouyang; Claudia Petritsch; Hong Wen; Lily Jan; Yuh Nung Jan; Bingwei Lu Drosophila neuroblasts have served as a model to understand how the balance of stem cell self-renewal versus differentiation is achieved. Drosophila Numb protein regulates this process through its preferential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1395–1407.
Published: 1 April 2011
..., LGN (Gpsm2) and NuMA, and the cell fate determinant Numb are asymmetrically localized in embryonic lung distal epithelium. Interfering with the function of these proteins in vitro randomizes spindle orientation and changes cell fate. We further show that Eya1 protein regulates cell polarity, spindle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 215–225.
Published: 15 January 2011
...Mark Rebeiz; Steven W. Miller; James W. Posakony The Notch cell-cell signaling pathway is used extensively in cell fate specification during metazoan development. In many cell lineages, the conditional role of Notch signaling is integrated with the autonomous action of the Numb protein, a Notch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (1): 53–61.
Published: 1 January 2010
... on Notch signaling, it is not necessarily dependent on numb , a gene classically involved in biasing Notch activation. When Numb was removed at the start of larval neurogenesis, both A and B hemilineages were still generated, but by the start of the third larval instar, the removal of Numb resulted in all...
Journal Articles
Journal: Development
Development (2010) 137 (1): 43–51.
Published: 1 January 2010
...Suewei Lin; Sen-Lin Lai; Huang-Hsiang Yu; Takahiro Chihara; Liqun Luo; Tzumin Lee Numb can antagonize Notch signaling to diversify the fates of sister cells. We report here that paired sister cells acquire different fates in all three Drosophila neuronal lineages that make diverse types of antennal...
Journal Articles
Journal: Development
Development (2009) 136 (24): 4089–4098.
Published: 15 December 2009
.... Antagonistic interactions between the Notch pathway and the intrinsic cell-fate determinant Numb appear to regulate asymmetric divisions in flies and vertebrates. During these divisions, productive Notch signaling requires sanpodo , which encodes a novel transmembrane protein. Here, we demonstrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3447–3458.
Published: 15 October 2008
... at this stage appears to be mediated by the transient expression of Numb in the hemangioblast-derived blast cell colonies. Activation of the Notch pathway was found to inhibit primitive erythropoiesis efficiently through the upregulation of inhibitors of the Wnt pathway. Together, these findings demonstrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2445–2454.
Published: 15 July 2008
...,and influences endoderm specification. To gain further insight into how the Notch signaling pathway is regulated during these cell specification events,we identified a sea urchin homologue of Numb (LvNumb). Previous work in other model systems showed that Numb functions as a Notch signaling pathway antagonist...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2425–2433.
Published: 1 July 2007
... to be important for asymmetric segregation of fate-determinants, such as Numb. Here,we show that an intermediate filament protein, transitin, colocalizes with Numb in the cell cortex of mitotic neuroepithelial cells, and that transitin anchors Numb via a physical interaction. Detailed immunohistological and time...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (17): 4109–4121.
Published: 1 September 2003
...Martha J. Lundell; Hyung-Kook Lee; Ernesto Pérez; Linda Chadwell Apoptosis is prevalent during development of the central nervous system(CNS), yet very little is known about the signals that specify an apoptotic cell fate. In this paper, we examine the role of Numb/Notch signaling...
Journal Articles
Journal: Development
Development (2003) 130 (13): 3039–3051.
Published: 1 July 2003
... differentiate without further divisions. Interestingly, the progenitors of asymmetric cell lineages adopt a myocardial cell fate as opposed to a pericardial fate when they are unable to divide. These progenitors adopt a pericardial cell fate,however, when cell division is blocked in numb mutants or in embryos...
Journal Articles
Journal: Development
Development (2003) 130 (11): 2329–2339.
Published: 1 June 2003
... asymmetrically distribute the cell-fate determinant Numb to the two daughter cells. Here, we test the possibility that such asymmetric divisions contribute to retinal cell diversification. We have used long-term videomicroscopy of green-fluorescent-protein (GFP)-labeled retinal explants from neonatal rats...
Includes: Multimedia, Supplementary data