.... * Author for correspondence (e-mail: efw@princeton.edu ) 16 4 2009 © 2009. 2009 Drosophila Mid-blastula transition Nucleocytoplasmic ratio Transcription Cell cycle The development of most metazoan embryos is characterized by a series of rapid, synchronous cell divisions...

... nine cycles, the nucleocytoplasmic ratio appears to govern the MBT. This timing mechanism operates cell autonomously: clones of labeled cells initiate cell cycle lengthening independently of neighbors but dependent on immediate lineal ancestors. Unequal divisions, when they occur, produce asymmetric...

...S. V. Evsikov; L. M. Morozova; A. P. Solomko ABSTRACT The hypothesis suggesting that the blastocoele is able to form only at a definite nucleocytoplasmic ratio was tested. We compared the development of preimplantation mouse embryos under different conditions. The results demonstrated...

...Ulrich Petzoldt; Audrey Muggleton-Harris The nucleocytoplasmic ratio of fertilized mouse eggs was manipulated by removing or injecting cytoplasm by micropipette, and bisection of denuded eggs to obtain both pronuclei in one half of the eggs cytoplasm. The experimental eggs were capable of cleavage...

... timing is not controlled by the number of cell divisions, DNA replication cycles, or the nucleocytoplasmic ratio. Cytoplasmic machinery with autonomous oscillatory properties is thought to be involved in the timing of these events. Copyright © 1985 by Company of Biologists 1985 temporal control...