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Keywords: Nuclear transfer
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev199901.
Published: 7 December 2021
... and gene targeting were exemplified in porcine stem cells. We further demonstrated that genetically modified AFX stem cells gave rise to cloned porcine foetuses by nuclear transfer. In summary, for major livestock mammals, pluripotent stem cells related to the formative embryonic disc are reliably...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev190777.
Published: 7 August 2020
... developmental potential of these RRF-reduced oocytes with MII-spindle shrinkage was not lost after fertilization. When somatic cell nuclear transfer was performed, the successful generation of cloned mice was somewhat improved and abnormalities were reduced when oocytes with slightly reduced RRF levels were...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4049–4055.
Published: 1 December 2015
... during early development and reprogramming. Xist Imprinted XCI Chromatin condensation Oogenesis Histone methylation Nuclear transfer Expression of the large non-coding RNA X inactive specific transcript ( Xist ) is essential for the initiation of X chromosome inactivation (XCI...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2468–2471.
Published: 15 June 2013
... by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation. * Author for correspondence ( rph32@cam.ac.uk ) Competing interests statement The authors declare...
Journal Articles
Journal: Development
Development (2012) 139 (23): 4330–4340.
Published: 1 December 2012
... through the exposure of nuclei to a GV cytoplasmic extract prior to somatic cell nuclear transfer (SCNT) to enucleated oocytes. Here, we developed an extract of GV stage pig oocytes (GVcyto-extract) to investigate epigenetic reprogramming events in treated somatic cell nuclei. This extract induced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2841–2847.
Published: 1 September 2010
... genome. Here, we show that parthenogenetic mouse embryonic cell nuclei can be reprogrammed by serial rounds of nuclear transfer without using any genetic modification. The durations of survival in uteri of cloned foetuses derived from green fluorescent protein (GFP)-labelled parthenogenetic cell nuclei...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3935–3945.
Published: 1 December 2008
... to decrease in 90% of injected oocytes after 1 hour ( Fig. 4A , part e and Fig. 4B , part e in SC). This became demethylated completely 7 hours after injection( Fig. 4A , part k and 4B, part k in SC). This was maintained during oocyte maturation (17 hours after nuclear transfer) ( Fig. 5A ; see Fig. S1A...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1597–1607.
Published: 15 April 2006
...Alice Jouneau; Qi Zhou; Anne Camus; Vincent Brochard; Linda Maulny; Jérôme Collignon; Jean-Paul Renard In mammals, cloning by nuclear transfer (NT) into an enucleated oocyte is a very inefficient process, even if it can generate healthy adults. We show that blastocysts derived from embryonic stem...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2269–2280.
Published: 15 May 2004
... Methylation Nuclear transfer Mammalian genomes with different parental origins are asymmetric in terms of their functions. This asymmetry comprises two biologically important phenomena. First, genomic imprinting causes some genes to be expressed in a manner that is dependent on parental origin, i.e...
Journal Articles
Journal: Development
Development (1990) 108 (Supplement): 81–87.
Published: 1 April 1990
...$xBALB/ccf)F, embryos. These experiments should help in our understanding of nucleocytoplasmic interactions and the respective roles of parental genomes in early embryonic development. Key words: DDK inbred mouse strain, preimplantation development, nuclear transfer, genomic imprinting, nucleocytoplasmic...
Journal Articles
Journal: Development
Development (1986) 97 (Supplement): 277–289.
Published: 1 October 1986
.... Copyright © 1986 by Company of Biologists 1986 nucleocytoplasmic interactions mouse embryo transplantation nuclear transfer interspecific haploid T hp mutation parthenogenones / . Embryol. exp. Morph. 97 Supplement, 277-289 (1986) 277 Printed in Great Britain © The Company of Biologists...