... by the sequential expression of the nuclear receptors E75, DHR3 and βFtz-f1, representing a model for steroid hormone signalling. Here, we have combined genetic and imaging approaches to investigate the precise role of this signalling cascade within theprothoracic gland (PG), where ecdysone synthesis takes place...

...Laura Palanker; Aleksandar S. Necakov; Heidi M. Sampson; Ruoyu Ni; Chun Hu; Carl S. Thummel; Henry M. Krause Nuclear receptors are a large family of transcription factors that play major roles in development, metamorphosis, metabolism and disease. To determine how, where and when nuclear receptors...

...Susan Y. Park; Joshua J. Meeks; Gerald Raverot; Liza E. Pfaff; Jeffrey Weiss; Gary D. Hammer; J. Larry Jameson Mutations of orphan nuclear receptors SF1 and DAX1 each cause adrenal insufficiency and gonadal dysgenesis in humans, although the pathological features are distinct. Because Dax1...

...: origin pinned down at last? Curr. Biol. 7 , R10 -2. Sachs, L. M., Jones, P. L., Havis, E., Rouse, N., Demeneix, B. A. and Shi, Y. B. ( 2002 ). Nuclear receptor corepressor recruitment by unliganded thyroid hormone receptor in gene repression during Xenopus laevis development. Mol. Cell. Biol...

... encoded by Hr (HR) functions as a nuclear receptor co-repressor. To address the role of HR in vivo, we generated a loss-of-function ( Hr -/- ) mouse model. The Hr -/- phenotype includes both hair loss and severe wrinkling of the skin. Wrinkling is correlated with increased cell proliferation...

...Julie Gates; Geanette Lam; José A. Ortiz; Régine Losson; Carl S. Thummel Pulses of the steroid hormone ecdysone trigger the major developmental transitions in Drosophila , including molting and puparium formation. The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer...

...Tatiana Kozlova; Carl S. Thummel Ecdysteroid signaling in insects is transduced by a heterodimer of the EcR and USP nuclear receptors. In order to monitor the temporal and spatial patterns of ecdysteroid signaling in vivo we established transgenic animals that express a fusion of the GAL4 DNA...

.... ‡Author for correspondence (e-mail: [email protected] ) 17 4 2001 © 2001. 2001 Drosophila Ecdysone Nuclear receptor GATAb serpent AEF-1 Fbp1 The specific gene transcription patterns formed during development of metazoans result from the activity of the cis...

... transactivation and cellular differentiation. J. Biol. Chem . 272 , 9443 -9449. Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. and Moras, D. ( 1995 ). Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 375 , 377 -382. Brocard, J., Kastner, P...

... that the mid-third instar response is dependent on a different signaling pathway under the control of the DHR78 nuclear receptor ( Fisk and Thummel, 1998 ). DHR78 mutants are arrested in their development during the third larval instar and fail to activate the mid-third instar regulatory hierarchy...

... regeneration nuclear receptor RAR retinoic acid fin Retinoic acid (RA), derived from vitamin A, appears to play an essential role in amphibian limb regeneration ( Brockes, 1990 ; Stocum and Maden, 1990 ; Tabin, 1991 ). The process of regeneration is a multifaceted one which begins with amputation...

... is not normally the critical regulatory step in the processes with which usp is involved. This contrasts with other Drosophila nuclear receptors such as tailless ( Steingrimsson et al., 1991 ) and other transcription factors, such as fushi tarazu ( Struhl, 1985 ), for which ectopic expression results...