...Olivia R. A. Tidswell; Matthew A. Benton; Michael Akam ABSTRACT The neuroblast timer genes hunchback , Krüppel , nubbin and castor are expressed in temporal sequence in neural stem cells, and in corresponding spatial sequence along the Drosophila blastoderm. As canonical gap genes, hunchback...

...-renewing asymmetric divisions. It is also not known how precursor cells undergo self-renewing asymmetric divisions. Here, we report that maintaining high levels of Mitimere or Nubbin, two POU proteins, in a GMC causes it to undergo self-renewing asymmetric divisions. These asymmetric divisions are due...

... of secreted signaling proteins that direct localized expression of transcription factors. The Drosophila homeodomain protein Distal-less is expressed in the leg primordia and required for formation of legs, but not wings. The homeodomain protein Nubbin is expressed in the wing primordia and required...

... of Nubbin and Wg. Besides its role in the establishment of the distal part of the PW, dve is also required for the formation of the wing veins 2 and 5, and the proliferation of wing pouch cells, especially in regions anterior to wing vein 3 and posterior to wing vein 4. The study of the regulation of dve...

... contexts. We present evidence that POU-domain protein Nubbin/PDM-1 is one of the factors that provide such context. The specific response of dbd and dda lineages to Notch activation suggests that factors specifically expressed in these lineages may provide the developmental contexts that allow Notch...