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Keywords: Notochord
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Journal Articles
Journal: Development
Development (2021) 148 (18): dev199459.
Published: 21 July 2021
...Susannah B. P. McLaren; Benjamin J. Steventon ABSTRACT How force generated by the morphogenesis of one tissue impacts the morphogenesis of other tissues to achieve an elongated embryo axis is not well understood. The notochord runs along the length of the somitic compartment and is flanked on...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev195230.
Published: 05 February 2021
...Wendy M. Reeves; Kotaro Shimai; Konner M. Winkley; Michael T. Veeman ABSTRACT The notochord is a defining feature of the chordates. The transcription factor Brachyury (Bra) is a key regulator of notochord fate but here we show that it is not a unitary master regulator in the model chordate Ciona...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192724.
Published: 18 November 2020
...Shiny Shengzhen Guo; Tiffany Y. K. Au; Sarah Wynn; Attila Aszodi; Danny Chan; Reinhard Fässler; Kathryn S. E. Cheah ABSTRACT The notochord drives longitudinal growth of the body axis by convergent extension, a highly conserved developmental process that depends on non-canonical Wnt/planar cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev175794.
Published: 06 October 2020
... development, and highlight open questions. We specifically focus on the processes of notochord development and cerebrospinal fluid physiology, and how defects in those processes may lead to scoliosis. * Authors for correspondence ( michel.bagnat@duke.edu , ryan.gray@austin.utexas.edu ) Competing...
Journal Articles
Journal: Development
Development (2018) 145 (9): dev159418.
Published: 08 May 2018
...-mineralized spine with gradually fusing vertebral body precursors (centra). However, the underlying cellular mechanisms remain incompletely understood. Here, we show that cells of the notochord epithelium named chordoblasts are sensitive to RA signaling. Chordoblasts are uniformly distributed along the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3375–3387.
Published: 15 September 2017
...Wendy M. Reeves; Yuye Wu; Matthew J. Harder; Michael T. Veeman The notochord of the ascidian Ciona consists of only 40 cells, and is a longstanding model for studying organogenesis in a small, simple embryo. Here, we perform RNAseq on flow-sorted notochord cells from multiple stages to define a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 244–254.
Published: 15 January 2016
... germ layer plasticity, these cells never give rise to midline tissues of the notochord, floor plate and dorsal endoderm, raising the question of whether midline tissues also arise from basal posterior progenitors after gastrulation. We show in zebrafish that local posterior signals specify germ layer...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2291–2303.
Published: 01 July 2015
...Magdalena Stasiulewicz; Shona D. Gray; Ioanna Mastromina; Joana C. Silva; Mia Björklund; Philip A. Seymour; David Booth; Calum Thompson; Richard J. Green; Emma A. Hall; Palle Serup; J. Kim Dale Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patterning of the overlying neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1733–1744.
Published: 15 May 2015
... notochord plays an instructive role in segmental patterning, alongside the somites, and contributes to mineralization. By clarifying the evolutionary relationship between centra and arches, and their varying modes of skeletal mineralization, we can better appreciate the detailed mechanisms that regulate and...
Journal Articles
Journal: Development
Development (2015) 142 (9): 1639–1650.
Published: 01 May 2015
...Elsa Denker; Ivonne M. Sehring; Bo Dong; Julien Audisso; Birthe Mathiesen; Di Jiang Regulation of lumen growth is crucial to ensure the correct morphology, dimensions and function of a tubular structure. How this is controlled is still poorly understood. During Ciona intestinalis notochord...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1516–1527.
Published: 15 April 2015
...-P axis elongation. Both genes regulate trunk notochord extension through PCP-controlled CE of notochord cells, establishing a role for Wnt11 in mammalian PCP. We show that Wnt5a and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation, and provide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 692–701.
Published: 15 February 2015
... against environmental and genetic variation that might otherwise perturb development and growth. (3) Force production is distributed between neural and mesodermal tissues in the dorsal isolate, and the notochord, a central structure involved in patterning vertebrate morphogenesis, is not required for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4569–4579.
Published: 01 December 2014
...Nicolas Buisson; Cathy Sirour; Nicole Moreau; Elsa Denker; Ronan Le Bouffant; Aline Goullancourt; Thierry Darribère; Valérie Bello Dystroglycan (Dg) is a transmembrane receptor for laminin that must be expressed at the right time and place in order to be involved in notochord morphogenesis. The...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4594–4601.
Published: 15 November 2013
...Diana Corallo; Alvise Schiavinato; Valeria Trapani; Enrico Moro; Francesco Argenton; Paolo Bonaldo The notochord is a transient and essential structure that provides both mechanical and signaling cues to the developing vertebrate embryo. In teleosts, the notochord is composed of a core of large...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2422–2433.
Published: 01 June 2013
...Diana S. José-Edwards; Izumi Oda-Ishii; Yutaka Nibu; Anna Di Gregorio T-box genes are potent regulators of mesoderm development in many metazoans. In chordate embryos, the T-box transcription factor Brachyury (Bra) is required for specification and differentiation of the notochord. In some...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (22): 4943–4953.
Published: 15 November 2011
... signaling. More broadly, genome-wide target extraction with validation using an in vivo tissue-specific sensor assay indicates that miR-124 shapes neuronal progenitor fields by downregulating non-neural genes, notably the muscle specifier Macho-1 and 50 Brachyury-regulated notochord genes, as well as...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2591–2600.
Published: 15 June 2011
...Hidehiko Hashimoto; Takashi Enomoto; Gaku Kumano; Hiroki Nishida In embryos of the ascidian Halocynthia roretzi , the competence of isolated presumptive notochord blastomeres to respond to fibroblast growth factor (FGF) for induction of the primary notochord decays by 1 hour after cleavage from the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2601–2611.
Published: 15 June 2011
... phenotype: a ventrally located secondary tail containing both somitic muscle and notochord. This phenotype has been proposed to reflect a fate-patterning defect due to a change in a hypothesized BMP activity gradient. Here, we show that a defect in morphogenetic movements, not fate patterning, underlies the...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1631–1641.
Published: 15 April 2011
...Bo Dong; Wei Deng; Di Jiang Cell elongation is a fundamental process that allows cells and tissues to adopt new shapes and functions. During notochord tubulogenesis in the ascidian Ciona intestinalis , a dramatic elongation of individual cells takes place that lengthens the notochord and...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2527–2537.
Published: 01 August 2010
... structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates...
Includes: Multimedia, Supplementary data