... activation relies on the correct localization of the Notch signalling actors. We report that AP-1 and Stratum ensure the basolateral targeting of Notch during asymmetric cell division. Notch signalling Intracellular trafficking Asymmetric cell division Stratum AP-1 Cell-cell signalling...

... asymmetric cell division, progenitors send a Delta-Notch signal to their sibling stem cells. Here, we show that excessive activation of Notch or overexpression of its direct targets of the Hes family causes stem-cell hyperplasias in the Drosophila larval central nervous system, which can progress...

.... Notch signalling regulates the balance between the rostral and caudal domains: high levels of Notch signalling expand the caudal domain at the expense of the rostral domain, whereas loss of Notch signalling produces the converse phenotype. Collectively, these data unravel a new patterning principle...

... of Notch signalling disrupts the maintenance of this zone. When Notch is blocked, progenitor cells differentiate precociously, the proliferative ventricular zone is lost and differentiation markers become expressed throughout the spinal cord. Comparison with other chordates suggests that the emergence...

... Photoreceptor Notch signalling Atonal homolog 7 Fibroblast growth factor 3 Neurogenin 2 Summary: The pigeon retina bears striking structural and functional similarities to the primate macula. Neurogenesis in this system shows a delayed onset, and is uncoupled from tissue growth. © 2016...

..., as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more...

... Drosophila oogenesis. Cc2d1a Aki Tape Dpp Lgd [L(2)gd1] Notch signalling Endocytosis In recent years, it has been established that the tumour suppressor gene lethal (2) giant discs ( lgd ) [ l(2)gd1 – FlyBase] has a function in the endosomal pathway and in the regulation...

... is a target of Notch signalling, whereas Dll1 is Wnt regulated. Regulation of Dll1 and Notch1 expression thus links the activity of Wnt and Notch, the two main signalling pathways driving the clock. * These authors contributed equally to this work ‡ These authors contributed equally to this work...

... dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate a new ISC and an enteroblast (EB) differentiating daughter. Notch signalling activity restricted to the EB regulates intestinal cell fate decision. Here, we show...

... that centrosome movements are controlled by the cell fate determinant Numb, which does not act via its classical effectors, Sanpodo and α-Adaptin, but via the Collapsin Response Mediator Protein (CRMP). Furthermore, we find that CRMP is necessary for efficient Notch signalling and that it regulates the duration...

... activation of Notch signalling. Consistent with the interpretation that the combination of Notch and Wnt signalling maintains crypt cells in a low proliferative state, the treatment of β-catenin-expressing mice with a Notch inhibitor turned such slow-cycling cells into actively proliferating cells. Our...

... involved in MHB establishment. Here, we present evidence for a role for Notch signalling in stabilising cell lineage restriction and regulating organiser gene expression at the MHB. Experimental interference with Notch signalling in the chick embryo disrupts MHB formation, including downregulation...

... ). Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta . Nature 375 , 761 - 766 . Crosnier C. , Vargesson N. , Gschmeissner S. , Ariza-McNaughton L. , Morrison A. , Lewis J. ( 2005 ). Delta-Notch signalling...

... declare no competing financial interests. 23 2 2011 © 2011. 2011 Cadherin Neural tube Chick RNAi Screen FatJ Progenitor cells Interneurons Phenotype Hippo pathway Notch signalling Morphogen Neural progenitor cells are patterned along the dorsoventral axis...

...Joana Neves; Carolina Parada; Mireia Chamizo; Fernando Giráldez Hair cells of the inner ear sensory organs originate from progenitor cells located at specific domains of the otic vesicle: the prosensory patches. Notch signalling is necessary for sensory development and loss of function of the Notch...

...Thimios A. Mitsiadis; Daniel Graf; Hansueli Luder; Thomas Gridley; Gilles Bluteau The Notch signalling pathway is an evolutionarily conserved intercellular signalling mechanism that is essential for cell fate specification and proper embryonic development. We have analysed the expression...

... and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates...

... but their in vivo role is not clear. The sole Drosophila Gas2-like gene, CG3973 ( pigs ), was recently identified as a transcriptional target of Notch signalling and might therefore link cell fate decisions through Notch activation directly to morphogenetic changes. We have generated a null mutant in CG3973 ( pigs...

...Nicolas Daudet; Linda Ariza-McNaughton; Julian Lewis Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as to generate a balanced mixture of sensory hair cells and supporting cells. Recently, however, we have found that ectopic Notch activity at an early...

... of the embryo, and loss of cyclic gene expression in the presomitic mesoderm. Analysis of cyclic genes in RPTP ψ morphant embryos indicates an important requirement for RPTP ψ in the control of the somitogenesis clock upstream of or in parallel with Delta/Notch signalling. Impairing RPTPψ activity also...